摘要
目的探讨化疗在晚期复治肿瘤患者治疗中的作用及不同化疗方式的应用意义。方法以回顾性研究方式收集整理了259例患者的临床资料,按接受不同治疗分为介入化疗组(A组)、减量热化疗组(B组)、常规静脉化疗组(C组),比较在不同肿瘤之间各组的临床总有效率、中位生存期(MST)及总生存率。结果A、B、C组肿瘤有效率分别为31.2%、20.0%和6.2%(A、B组与C组相比,P<0.01),中位生存期分别为6.20、9.87和6.78个月。3组近期生存率差异无显著性,但23年生存率以热化疗(B组)为高,分别为33.3%及12.5%。结论单纯静脉化疗肿瘤缓解率较低,介入化疗有效率较高,但并不一定延长生存率;减量热化疗在提高复治患者的有效率,延长生存期方面有积极意义。
Objective To study the efficacy and significance of different methods of chemotherapy in treating malignant tumor. Methods 259 cases were divided into 3 groups according to different chemotherapy methods： the group of interventional chemotherapy （ A）, whole body hyperthermia combined with chemotherapy （B） and only chemotherapy （ C ）, for comparing response rate （RR） of the tumour, median survival time （MST）, and overall survival rate. Results the RR in group A, B, C were 31.2% ,20.0% and 6.2% respectively（ groups A and B compared with group C, P 〈 0.01 ）. The MST were 6.20 months, 9.87 months and 6.78 months respectively. The short-term survival rate had no significant difference,but survival rates in 2-3 years were 33.3% and 12.5% ,with highest in group B. Conclusion The RR in only chemotherapy group was lower than other 2 groups. The RR in interventional chemotherapy group is highest, but the survival rate was not prolonged by treatment with interventional chemotherapy, and whole body hyperthermia combined with chemotherapy has active significance in improving response rate and prolonging the survival time of the patients with advanced tumor having been treated previously.
出处
《中国肿瘤临床与康复》
2006年第6期506-508,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
肿瘤
介入化疗
热化疗
常规化疗
Neoplasms
Interventional chemotherapy
Whole body hyperthermia combined with chemotherapy
Conventional chemotherapy
