摘要
目的:观察慢性心力衰竭联用螺内酯和比索洛尔的临床效应。方法:选择96例慢性心力衰竭患者,随机分为对照组48例和观察组48例,对照组采用常规治疗,观察组在常规治疗基础上加用螺内酯联合比索洛尔。在治疗前和观察期满12周时,分别进行测定心率、血压、血清钾离子浓度、肾功能及心脏超声检测左室收缩末期内径(LVEDs),左室舒张末期内径(LVEDd)和左室射血分数(LVEF)。结果:治疗12周后,总有效率95．8％、心率明显下降、心脏LVEDs及LVEDd缩小,LVEF提高均有统计学意义(P<0．05)。结论:螺内酯联合比索洛尔治疗慢性心力衰竭疗效确切,无明显不良反应。
Objective： To observe the clinical effect on the treatment of the patients with chronic heart failure by using both spironolactone and Bisoprolol. Method： 96 patients with chronic heart failure were selected to be randomly assigned in the control group and the test group, each with 48 patients. The routine treatment was used in the control group, while the combination of spironolactone and Bisoprolol was used in the test group on the basis of the routine treatment. Some tests were given before the treatment such as the measure of heart rate, blood pressure, serum potassium ion concentration; the test of renal function, the ultrasonic examinations of left ventricular end-systolic diameter （LVEDs）, left ventricular end-diastolic diameter （LVEDd）, and left ventricular ejection fraction （LVEF）, and the same tests were redone after 12 weeks＇ observation. Result： After 12 weeks＇ treatment, the total effective rate is 95.8%. The result has proved to be statistic significance with the evident decrease of the heart rate, the diminution of LVEDs and LVEDd, the increase of LVEF （P〈0.05）. Conclusion： The combined use of the two drugs is indeed effective to treat the chronic heart failure without distinct adverse reaction.
出处
《大理学院学报（综合版）》
CAS
2006年第12期34-36,共3页
Journal of Dali University
关键词
慢性心力衰竭
螺内酯
比索洛尔
疗效
chronic heart failure
spironlactone
bisoprolol
curative effect
