摘要
目的探讨腹腔镜子宫切除术(laparoscopyhysterectomy,LH)和开腹子宫切除术(abdominalhys-terectomy,AH)对机体免疫功能的影响。方法选择因良性疾病需行LH术的患者32例作为研究对象(LH组);对照组为同期在该院行AH且条件相似的患者28例(AH组)。测定两组术前1d和术后1、4d外周血T细胞亚群及单核细胞HLA-DR的表达水平。结果2组术后1d外周血CD3+、CD4+T细胞较术前均有不同程度的下降(均P<0.05),但AH组上述指标显著低于LH组(P<0.05),术后4dLH组CD3+、CD4+T细胞与术前差异无显著性(均P>0.05),AH组仍明显低于术前(均P<0.05),两组相比差异有显著性(P<0.05);2组术后CD8+T细胞均稍有下降,但无统计学意义(均P>0.05)。两组术后1d外周血单核细胞HLA-DR表达水平明显低于术前(均P<0.05),组间差异无统计学意义(P>0.05);术后4d两组均有升高趋势,但仍明显低于术前(P<0.05),两组相比,LH组明显高于AH组(P<0.05)。结论比较研究的结果证明了LH对机体免疫功能的损伤大大低于AH。
[Objective] To study the effect of laparoscopic hysterectomy（LH） and abdominal hysterectomy（AH） on immune function. [Methods] 32 women who suffered from gynaecol benign diseases and had hysterectomy signs were chosen.undergoing（LH group）, 28 patients undergoing abdominal hysterectomy who had simlar condition were chosen at the same time （AH group）. T lymphocyte Subsets and Expression of Human Leukocyte Antigen-DR on Monocytes in Peripheral Blood at 1 day before and 1 and 4 days after operation were measured. [Results] ①Postoperative levels of CD3^＋, CD4^＋ in two groups decreased significantly at 1 day after operation （P 〈0.05）, but were lower in AH group than them in LH group（P 〈0.05）, At the same time they were also lower significantly in AH group at 4 day after operation（P 〈0.05）,but not in LH group（P 〉0.05）,there was greater difference between two groups（P 〈 0.05）. The level of CD8^＋; decreased slightly after operation in two groups（P 〉0.05）. ② Monocyte HLA-DR expression decreased markedly on day 1 after operation in both LH and AH groups（P 〈0.05）, there was no significant difference between two groups （P 〉0.05）. On day 4, HLA-DR expression increased in both groups, but there was marked difference between two groups（PP 〈0.05）. [ Conclusion] The results show that LH caused less injury on immune function than AH.
出处
《中国内镜杂志》
CSCD
北大核心
2006年第12期1255-1257,1260,共4页
China Journal of Endoscopy
关键词
腹腔镜术
开腹术
子宫切除术
免疫功能
比较研究
laparoscopy
abdominal hysterectomy
immune function
comparative research
