期刊文献+

胃癌发病风险与醌氧化还原酶基因多态性的关系 被引量:7

NAD(P)H: quinone oxidoreductase gene polymorphism association with gastric carcinoma
下载PDF
导出
摘要 目的:探讨醌氧化还原酶基因多态性与胃癌发病的关系。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-R FLP)分析方法分析了80例胃癌患者与80名健康成人NQ01的基因多态性。结果:醌氧化还原酶基因cDNA609位T等位基因频率在胃癌组和对照组分别为55%和42.5%,两组比较差异有统计学意义,x^2=5.00,P=0.018。基因型分布在胃癌组和对照组之间差异有统计学意义,x^2=7.63,P=0.025。杂舍型(T/C)和突变纯舍子型(T/T)基因型携带者患胃癌的危险性分别是野生型纯合子(C/C)的2.84倍(95%CI:1-2451~6.4780)与3.60倍(95%CI:1.2970~9.9925)。结论:NQ01cDNA609 T等位基因可能是胃癌发生的危险性因素,与胃癌的发生有关。 OBJECTIVE:To explore whether gastric carcinoma was associated with genetic polymorphism of NQO1 gene (NAD(P) H .. guinone oxidoreductase gene) caused by the point mutation of cDNA609 C to T. METHODS: The polymorphism of NQO1 gene was analyzed in 80 patients with gastric carcinoma and 80 unrelated healthy adult individuals by utilizing the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. RESULTS.. The frequencies of T allele were 55% and 42.5% in the gastric carcinoma group and the health control group respectively, being significantly different between the two groups (x^2 =5.00, P=0. 018). The allelic frequency of the mutant T allele was significantly higher in the gastric carcinoma patients as compared with the controls. There was a significant difference in the overall genotypic distribution between the patients and the controls (x^2= 7.63, P=0. 025). The risk of suffering from gastric carcinoma was increased 2.84 times in the individuals with T/C genotype (95% CI: 1.2451- 6. 478 0) and 3.60 times in the individuals of T/T genotype of NQO1 gene (95% CI:I. 297 0-9. 992 5). CONCLUSION:The cDNA609 T allele of NQO1 gene may be the risk factor of gastric carcinoma, which can be associated, with genetic susceptibility of gastric carcinoma.
出处 《中华肿瘤防治杂志》 CAS 2006年第22期1686-1688,共3页 Chinese Journal of Cancer Prevention and Treatment
关键词 胃肿瘤 醌氧化还原酶 基因多态性 gastric carcinoma quinone oxidoreductase gene polymorphism
  • 相关文献

参考文献5

二级参考文献18

  • 1Lin Cai Shun-Zhang Yu Zuo-Feng Zhang Department of Epidemiology.Fujian Medical University,Fuzhou 350004,Fujian Province,ChinaDepartment of Epidemiology,Shanghai Medical University,Shanghai 200032,China Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA.Glutathione S-transferases M1,T1 genotypes and the risk of gastric cancer:A case-control study[J].World Journal of Gastroenterology,2001,7(4):506-509. 被引量:22
  • 2Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA.Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province[J].World Journal of Gastroenterology,2001,7(6):792-795. 被引量:26
  • 3钱彦丛,秦百宣,靳新营,秦葵.红景天研究新进展[J].中药材,1994,17(8):43-45. 被引量:33
  • 4Chan P,Mov Disord,1997年,12卷,增刊,26页
  • 5Chan P,Movem Diso,1997年,12卷,增刊,26页
  • 6Itoh K,Chiba T,Takahashi S,et al.An Nrf2/small maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements[].Biochemical and Biophysical Research Communications.1997
  • 7Jaiswal AK.Regulation of genes encoding NAD ( P) H:Quinone oxidoreductases[].Free Radical Biology and Medicine.2000
  • 8Joseph P,Klein SA,Jaiswal AK.Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis[].British Journal of Cancer.1998
  • 9Wilkinson JIV,Radjendirane V,Pfciffer GR,et al.Disruption of c-Fos leads to increased expression of NAD(P)H: quinone oxidoreductase 1 and glutathione S-transferase[].Biochemical and Biophysical Research Communications.1998
  • 10Martin A,Cerain A,Hamilton E,et al.DT-diaphorase and cytochrome B5 reductase in human lung and breast tumors[].British Journal of Cancer.1997

共引文献48

同被引文献78

引证文献7

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部