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不同麻醉方法对老年患者术后早期认知功能的影响 被引量:29

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摘要 目的:通过简易智能状态检查法(MMSE)行神经心理学的测试,调查不同麻醉方法对老年患者术后早期认知功能的影响。方法:选择无明显呼吸、循环系统疾病,排除有精神、神经系统疾病史或服用相应药物老年患者80例,随机分成二组,每组40例,根据患者受教育程度每组又分三亚组。E组(椎管内麻醉组)采用腰麻联合硬膜外麻醉,G组(全麻组)采用静吸复合、气管内插管麻醉。G组维持呼气末二氧化碳分压(PETCO2)在30~40mmHg。两组患者术中收缩压变化维持在基础值的±25%之内,脉搏血氧饱和度(SpO2)95%以上。记录患者受教育程度、年龄、手术类型、手术时间;记录患者麻醉前,术后3h、6h、1d、3d的Bp、HR、SPO2及MMSE评分、术后认知功能障碍的发生率。结果:全麻组MMSE评分在术后3h、6h、1d时与麻醉前比较差异有统计学意义(P<0.05),椎管内麻醉组、两组的各亚组MMSE评分在术后3h、6h时与麻醉前比较差异有统计学意义(P<0.05);组间比较,在3h、6h时差异有统计学意义(P<0.05);其各亚组在术后1d、3d时与麻醉前比较、组间比较差异无统计学意义(P>0.05)。全麻组术后3h、6h各有13例(占33%)和7例(占18%)发生术后认知障碍,椎管内麻醉组各有2例(占5%)和1例(占3%),两组间比较差异有统计学意义(P<0.05)。结论:全麻患者术后早期MMSE评分下降较椎管内麻醉者明显,术后认知障碍的发生率明显高于椎管内麻醉者。术后认知功能在术后1d~3d基本能恢复正常。
出处 《温州医学院学报》 CAS 2006年第6期573-575,共3页 Journal of Wenzhou Medical College
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