摘要
目的比较背驮式原位肝移植术中持续输注小剂量多巴胺或呋塞米和多巴胺联合应用对无肝期肾功能和尿量的影响。方法 背驮式原位肝移植术患者42例，ASAⅢ～Ⅳ级，随机分为多巴胺组（D组）和呋塞米-多巴胺组（F组），每组21例。两组均于麻醉诱导后静脉泵注多巴胺（2～5μg·kg^-1·min^-1）至术毕，F组则在无肝期开始时静注呋塞米0．1mg／kg。观察无肝期输液量、血液动力学和尿量，检测疯清肌酐（Cr）和肌酐清除率（CCr）。结果与D组比较，F组无肝期尿量明显增多（P〈0．05）；两组无肝期时间、输液量和心率（HR）、平均动脉压（MAP）、中心静脉压（CVP）、每搏量（SV）、心输出量（CO）、全身血管阻力（TSVR）、Cr、CCr差异无显著意义。结论肝移植术中持续泵注多巴胺和呋塞米联合应用可明显增加无肝期尿量。
Objective To evaluate the effects of low-dose dopamine;of furosemide combined with dopamine on renal function and urine output during anhepatic phase. Methods Forty-two ASA class m or patients with end-stage liver diseases undergoing piggy-back liver transplantation were randomly divided into two groups with 21 patients each. Dopamine was infused at the rate of 2-5μg·kg^-1·min^-1 in group D and F after induction until the end of operation. Furosemide 0.1 mg/kg was given intravenously in group F at the beginning of anhepatic phase. Venous blood samples were taken and urine was collected during anhepatic phase for determination of serum creatinine（Cr） concentration and creatinine clearance ratio（CCr） was calculated. Results There was significantly more urine output during anhepatic phasein group F than that in group D（P〈0.05）. There were no significant differences in MAP, CO, HR, SV, CVP, TSVR, Cr and CCr during anhepatic phase between two groups. Conclusion Furosemide combined with low dose dopamine is more effective in increasing urine output during anhepatic phase than low dose dopamine alone.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第12期909-911,共3页
Journal of Clinical Anesthesiology
基金
陕西省社发攻关项目(2005K09-G12)
关键词
肝移植
肾功能
呋塞米
多巴胺
Liver transplantation
Renal functioni Furosemide
Dopamine
