摘要
目的:探讨热性惊厥(FC)患儿血清神经元特异性烯醇酶(N SE)变化的临床意义。方法:选择单纯性FC 37例、复杂性FC 17例和对照组患儿30例,用EL ISA法测定其血清中的NES质量浓度,并于FC发作2周后检查脑电图。结果:复杂性FC患儿血清NES质量浓度明显高于单纯性组和对照组(P均<0.01),单纯性FC组和对照组比较则差异无统计学意义(P>0.05)。脑电图异常患儿血清NES质量浓度明显高于脑电图无异常者和对照组(P均<0.01),脑电图无异常组和对照组比较差异无统计学意义(P>0.05)。惊厥发作持续时间≥15 m in FC患儿血清NES质量浓度明显高于发作持续时间<15m in者和对照组(P均<0.001),发作持续时间<15m in组和对照组比较则无明显差异。结论:复杂性FC惊厥发作可引起患儿脑损伤,这种损伤可能与发作持续时间有关。
Objective, To study the clinical significance of serum neuron specific enolase （NES） in children with febrile convulsion （FC）. Methods, Serum levels of NES were detected by ELISA in 54 children with FC （simple FC, n=37; complex FC, n=17） and 30 controls. All patients with FC received electroencephslogram （EEG） 2 weeks after the attack of FC. Results ： Serum levels of NES were higher in complex FC than those in simple FC group （P〈0. 001） and control group （P〈0. 01）, especially in patients with abnormal EEG and duration of FC being 15 min or more, but there was no statistical difference in serum levels of NES between simple FC and control group （P〉0.05）. Conclusion.. The complex FC may induce the damage of brain, which could be related to the duration of FC.
出处
《广东医学院学报》
2006年第6期572-573,共2页
Journal of Guangdong Medical College
