摘要
目的:调查依替米星联用其他抗菌药对老年重症肺炎患者肾功能的影响。方法:对47例依替米星联用其他抗菌药治疗的老年重症肺炎患者进行回顾性分析。47例老年患者中,32例为60～79岁,15例>80岁,观察患者治疗前后血清肌酐(Scr)、血尿素氮(BUN)及尿蛋白变化情况,计算内生肌酐清除率(Ccr)。结果:47例患者在依替米星治疗前,Scr、BUN、Ccr均值分别为106±26.5μmol/L、6.3±2.9mmol/L、44±14ml/min;用药后Scr、BUN均值分别下降为97±17.7μmol/L和5.4±2.6mmol/L,Ccr均值升高为46±13ml/min。但治疗前后的这些数据差异无统计学意义(P>0.05)。患者的尿蛋白明显下降(P<0.01)。结论:依替米星联用其他抗菌药治疗老年重症肺炎患者未见明显肾毒性,是一种较为安全的疗法。
Objective： To investigate the effects of etimicin plus other antibacterials on renal function in elderly patients with severe pneumonia. Methods： Forty-seven elderly patients with severe pneumonia who were receiving etimicin plus other antibacterials were analysed retrospectively. Of the 47 elderly patients, 32 were 60-79 years old, 15 were old than 80 years. The changes in serum creatinine （Scr）, blood urea nitrogen （BUN）, and urine protein were observed before and after treatment,and ereatinime clearance rate （Cer）were calculated. Results： Before etimiein treatment, the mean value of Ser, BUN and Cer in the 42 patients were 106±26.5 μmol/L, 6.3±2.9 mmol/L, and 44±14 ml/min respectively. After etimicin treatment, the mean value of Set and BUN were reduced to 97±17.7 μmol/L and 5.4±2.6 mmol/L, respectively, and Cer was elevated to 46±13 ml/min. But there were no statistical differences between before treatment and after treatment in their data （P 〉 0.05）. Urine protein was decreased obviously after treatment （P〈0.01）. Conclusion： There is no marked renal toxicity of etimiein plus other antibaeterials in the treatment of the elderly patients with severe pneumonia, so it might be a safer therapy for the patients.
出处
《药物不良反应杂志》
2006年第6期428-430,共3页
Adverse Drug Reactions Journal
关键词
依替米星
肺炎
肾功能
etimicin
pneumonia
renal function
