摘要
目的改良原有新斯的明结果判定方法，为临床提供科学、准确、适用的评定方法以更好辅助重症肌无力（MG）临床诊断。方法对23例正常对照者及68例曾确诊为MG且病情出现反复的患者行新斯的明试验：甲基硫酸新斯的明1．5mg配以阿托品1．0mg肌肉注射，记录注射前及注射后每10min（直至注射后60min）的各项指标绝对评分及相对评分，并统计分析其阳性界定值的敏感性和特异性。结果以任一指标相对评分值超过60％为阳性标准，其敏感性和特异性分别达到88％、89％；25％～60％为可疑；小于25％为阴性标准，其敏感性和特异性分别达到89％、90％。结论该研究提供了客观、准确、简便、适用的新斯的明试验评定方法，为临床MG诊断提供了更为可靠的辅助手段。
Objective To revive the criteria for neoStigmine test, and prove a scientific, accurate, applicable method to help diagnosis of myasthenia gravis （MG）. Methods Neostigmine （1.5 mg） and atropine （1.0 mg） were intramuscularly administered for 68 cases with clinical confirmed MG and 23 healthy control cases. The clinical absolute and relative scores of each item were recorded quantitatively before and every 10 minutes after intramuscular injection of neostigmine. Results The test result was positive when each item relative score was over 60%, 25%-60% was possible positive and under 25% was negative. Conclusions The criteria of neostigmine test established in this study is objective, accurate, easy and applicable for MG diagnosis.
出处
《中国神经免疫学和神经病学杂志》
CAS
2007年第1期1-3,共3页
Chinese Journal of Neuroimmunology and Neurology
