摘要
目的探讨鸡冠花乙醇提取物对大鼠血脂、脂质过氧化物及脂肪肝的影响．方法ＳＤ大鼠３０只，２４０±２５ｇ，雄性．随机分为高脂对照组（简称对照组）、牛磺还组和鸡冠花组，每组１０只，各组均喂给高脂饲料，建立高脂动物模型，鸡冠花组通过预防性给予鸡冠花提取物１００ｍｇ／ｋｇ８ｗｋ，牛磺程组给牛磺酸１００ｍｐ／ｋｇ．８ｗｋ，于实验４Ｗｂ和８Ｗｋ测血脂、ＭＤＡ等，并进行比较。结果对照组实验第４Ｗｋ后血脂及ＭＤＡ明显升高，鸡冠花组和牛磺酸组经过预防性给药，与对照组比血脂和ＭＤＡ明显降低（Ｐ＜０．０５），肝组织经病理检查：与实验组相比，对照组肝脏切ＸＭ下观脂肪空泡增多，肉眼观肝脏明显肿大，肝／体比值明显增加（Ｐ＜０．０１）．结论鸡冠花乙醇提取物和牛磺酸具有降低血脂、ＭＤＡ及预防脂肪肝的作用．
Objective To research the effeCts of the taurineand extractS of Cristata L on lipids, lipidPeroxidation.Matholl Thirty SD ratS,were randorlily divided ifito three group' control group, taurinegroup and cristata L group. Cristata LgrourtCRT) was fed with alcohol extraCts ofCristata L.100mg/kg. swk. the tauriregroup(TAU) was fed taurine 10()mg/ kg.swk,The comparison was made about lipids andMDA etc in the experiment of the fourth weekand the eighth week.Result Because of preventive feeding tO thegroup CRT andTAU,their lipids and MDA wereclearly lowertp< 0.05 and P< 0.01) res￣ivelythan control group .The livers of the contral groupwere clear enlargement and fat vacuoler increasedafter their liver tissue was mythologiCally exandnedand seen with naked eyeS. The ratio of the liverand the weight were obviously larger than groupTAU.Concluaion Cristata L and tuurine possessesthe actions of lowing lipids and MDA and mayprevent fatty liver.
出处
《新乡医学院学报》
CAS
1996年第4期338-341,共4页
Journal of Xinxiang Medical University
基金
河南省教委资助
