摘要
基质金属蛋白酶(matrixmetalloproteinases,MMPs)是一组可降解细胞外基质(extracellularmatrix,ECM)和其它蛋白的锌依赖性肽链内切酶类,MMPs通过对ECM成分的水解影响其水解与重组的动态平衡,参与多种细胞的生理和病理过程,并能在炎症过程中发挥作用。近年发现,MMPs参与了脑缺血(cerebralischemia)、阿尔采末病(Alzheimerdis-ease,AD)、多发性硬化病(multiplesclerosis,MS)、帕金森病(Parkinsondisease,PD)等多种神经疾病的发生、发展。
Matrix metalloproteinases （MMPs） are a family of Zn^2＋-dependent endopeptidases targeting extracellular matrix （ECM） compounds as well as a number of other proteins. Their proteolytic activity acts as an effector mechanism of tissue remodeling in physiologic and pathologic conditions, and as modulator of inflammation. Recently, it has been reported that MMPs play an important role in nervous diseases including cerebral ischemia, Alzheimers disease, multiple sclerosis and Parkinson＇s disease.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2007年第1期8-12,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30470587)
