期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

唑类抗真菌药物结构修饰的研发进展 被引量：1

Progress of the Structural Modification on Antifungal Azoles
下载PDF
导出
摘要 唑类药物是治疗真菌感染的主要用药,按化学结构分为咪唑类和三唑类。现综述了唑类药物近年来结构修饰和构效关系的研究进展,为进一步的新药研究提供线索。 The azole antifungals including imidazoles and triazoles are the mainstay in clinical treatment of fungal infections. In this paper, their structural modification and structure-activity relationship are reviewed in order to give some clues for the further research.
作者 王思袭 王峥 蔡正艳 周伟澄
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第1期49-57,共9页 Chinese Journal of Pharmaceuticals
关键词 三唑 抗真菌 结构修饰 合成 综述 triazoles antifungal structural modification synthesis review
分类号 R978.5 [医药卫生—药品]
  • 相关文献

参考文献35

  • 1McNeil MM,Nash SL,Hajjeh RA,et al.Trends in mortality due to invasive mycotic diseases in the United States,1980-1997[J].Clin Infect Dis,2001,33 (5):641-647.
  • 2Gunay NS,Capan G,Ulusoy N,et al.5-Nitroimidazole derivatives as possible antibacterial and antifungal agents[J].Farmaco,1999,54 (11-12):826-831.
  • 3Saha AK,Liu L,Simoneaux RL,et al.Novel antifungals based on 4-substituted imidazole:a combinatorial chemistry approach to lead discovery and optimization[J].Bioorg Med Chem Lett,2000,10 (19):2175-2178.
  • 4Hori K,Sakaguchi A,Kudoh M,et al.Structure-activity relationships of a new antifungal imidazole,AFK-108,and related compounds[J].Chem Pharm Bull(Tokyo),2000,48 (1):60-64.
  • 5Menozzi G,Mosti L,Bruno O,et al.Synthesis and biological evaluation of[α-(1,5-disubstituted 1H-pyrazol-4-yl) benzyl] azoles,analogues of bifonazole[J].Farmaco,1999,54 (6):416-422.
  • 6Fioravanti R,Biava M,Porretta GC,et al.N-Substituted 1 -aryl-2-(1H-imidazole-l-yl)-1 -ethanamines with broad spectrum in vitro antimycobacterial and antifungal activities[J].Med Chem Res,1997,7 (2):87-97.
  • 7Uchida K,Nishiyama Y,Yamaguchi H.In vitro antifungal activity of luliconazole (NND-502),a novel imidazole antifungal agent[J].J Infect Chemother,2004,10(4):216-219.
  • 8Niwano Y,Kuzuhara N,Kodama H,et al.In vitro and in vivo antidermatophyte activities of NND-502,a novel optically active imidazole antimycotic agent[J].Antimicrob Agents Chemother,1998,42 (4):967-970.
  • 9Matysiak J,Niewiadomy A,Krajewska-Kulak E,et al.Synthesis of some 1-(2,4-dihydroxythiobenzoyl) imidazoles,-imidazolines and -tetrazoles and their potent activity against Candida species[J].Farmaco,2003,58 (6):455-461.
  • 10Castellano S,La Colla P,Musiu C,et al.Azole antifungal agents related to naftifine and butenafine[J].Arch Pharm (Weinheim),2000,333 (6):162-166.

二级参考文献46

  • 1盛春泉,张万年,季海涛,宋云龙,杨松,周有骏,朱驹,吕加国.1-(1,2,4-三唑-1H-1-基)-2-(2,4-二氟苯基)-3-(4-取代苄基-1-哌嗪基)-2-丙醇的合成及抗真菌活性[J].药学学报,2003,38(9):665-670. 被引量：5
  • 2王文莉,王端礼,李世荫,李若瑜,万哲,王晓红.NCCLS方案检测氟康唑对酵母菌的最小抑菌浓度[J].中华皮肤科杂志,1996,29(5):374-376. 被引量：13
  • 3Boschman CR,Bodnar UR,Tornatore MA,Thirteenyear evolution of azole resistance in yeast isolates and prevalence of resistant strains carried by cancer patient at a large medical center[J].Antimicrob Agents Chemother,1998,42:734-738.
  • 4Maher MB,Steven DL,Pranab KM,et al.Mechanisms of fungal resistance[J].Drugs,2002,62(7):1025-1040.
  • 5Goldani LZ,Mario PS.Candida tropicalis fungemia in a teriary care hospital[J].Journal of Infection,2003,46:155-160.
  • 6Richardson K.Antifungal 1,3-bis-trizolyl-2-propanol derivative[P].GB:209918,1982-12-15.
  • 7Maher MB,Steven DL,Pranab KM,et al.Mechanisms of fungal resistance[J].Drugs,2002,62(7):1025-1040.
  • 8Goldani LZ,Mario PS.Candida tropicalis fungemia in a teriary care hospital[J].Infection,2003,46(3):155-160.
  • 9Boschman CR,Bodnar UR,Tornatore MA.Thirteen-year evolution of azole resistance in yeast isolates and prevalence of resistant strains carried by cancer patient at a large medical center[J].Antimicrob Agents Chemother,1998,42(4):734-738.
  • 10刘超美 孙青龚.取代丙基三唑类抗真菌化合物和其盐类以及制备方法[P].中国专利:1324792A.2001-12-05.

共引文献47

同被引文献27

  • 1刘杰.浅谈80%乙蒜素应用技术[J].农药市场信息,2009(12):38-38. 被引量：4
  • 2李储君,盛建伟,任怡,郭春.抗真菌药兰诺康唑的合成[J].中国药物化学杂志,2006,16(2):88-90. 被引量：6
  • 3李伟,常选妞,郝二军,何新蕾.利拉萘酯的合成工艺改进[J].中国药物化学杂志,2006,16(2):106-107. 被引量：5
  • 4唐辉,朱驹,周有骏.抗真菌药物研究现状及发展趋势[J].药学进展,2006,30(12):529-535. 被引量：8
  • 5LEE SH. Disulfide and multisulfide antitumor agents and their modes of action[ J]. Arch Pharm Res,2009,32(3 ) : 299 - 315.
  • 6MONDE K,TANIGUCHI T, MIURA N. Chiral cruciferous phytoa- lexins: Preparation, absolute configuration, and biological activi- ty[J]. Bioorg Med Chem,2005,13(17) : 5206 -5212.
  • 7PEDRAS MSC, SUCHY M, AHIAHONU PWK. Unprecedented chemical structure and biomimetic synthesis of erucalexin, a phy- toalexin from the wild crueiferErucastrum gaUicum [ J ]. Org Bio- mol Chem, 2006,4 (4) :691 - 701.
  • 8KUTSCHY P, SALAYOVA A,CURILLOVA Z,et al. 2-( Substitu-ted phenyl) amino analogs of 1-methoxyspirobrassinol methyl e- ther: Synthesis and anticancer activity [ J]. Bioorg Med Chem, 2009,17 (10) : 3698 - 3712.
  • 9FOKIALAKIS N, CANTRELL CL, DUKE SO, et al. Antifungal activity of thiophenes from echinops fitro[ J ]. J Agric Food Chem, 2006,54(5) : 1651 - 1655.
  • 10LIMA B, AGUERO MB,ZYGADLO J,et al. Antimicrobial activity of extracts, essential and metabolites obtained from tagetes men- docina[ J]. J Chil Chem, 2009,54 (1) : 68 -72.

引证文献1

二级引证文献1

中国医药工业杂志
2007年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部