摘要
目的探讨阿托伐他汀治疗急性脑出血(ICH)脑水肿的作用机制。方法ICH患者103例,随机分为治疗组52例和对照组51例。治疗组在静滴甘露醇的基础上给予阿托伐他汀口服,10 m g/d,共14 d。观察治疗前后患者MM P-2和MM P-9水平的变化。结果治疗组入院后第1、2、3周神经功能评分增加值均高于对照组,水肿产生量小于对照组,治疗后血浆MM P-2和MM P-9水平低于对照组,差异均有统计学意义。结论阿托伐他汀能够抑制ICH患者脑水肿的形成,与降低血浆MM P-2和MM P-9水平,减少血脑屏障的开放有关。
[Objective] To investigate the mechanism of atorvastatin in treatment of cerebral hemorrhage. [Methods] 103 patients with, intraeerebral hemorrhage were divided into two groups： atorvastatin ,treating group （52 cases） and control group （51 cases）. The atorvastatin treating group was treated with mannitol and atorvastatin（10 mg/d）. MMP-2 and MMP-9 were measured by ELISA ,method before and after treatment. [Results] The therapeutic effects in the atorvastatin treating group were significantly higher than those in the control group. The production of edema per day in the atorvastatin treating group was significantly less than that in the control group. The levels of MMP-2 and MMP-9 in the atorvastatin treating group were significantly less than those in the control ＇group, [Conclusion] Atorvastatin may inhibit the formation of cerebral edema and improve the neurologic function marks after attacks. The mechanism related to the decrease of contents of MMP- 2 and MMP-9 and inhibition the opening of blood-brain barrier.
出处
《山东医药》
CAS
北大核心
2007年第1期11-12,共2页
Shandong Medical Journal
关键词
阿托伐他汀
脑出血
脑水脚
基质金属蛋白酶
atorvastatin
brain hemorrhage
brain edema
matrix metalloproteinase
