摘要
目的探讨重组组织型纤溶酶原激活物（r-tPA）静脉溶栓与轻度低温联合治疗急性脑梗死的效果。方法对照组急性脑梗死患者22例，给予r—tPA0．7～0．8mg／kg静滴，60min滴完；低温组急性脑梗死患者18例，在上述治疗基础上辅以降温毯。结果两组治疗后神经功能缺损评分较治疗前均有明显改善，低温组溶栓治疗7d后改善情况优于对照组；低温组治疗后7d血浆磷脂酶A2（Lp—PLA2）活性和高敏C反应蛋白（hsCRP）水平明显低于对照组。结论r-tPA静脉溶栓与轻度低温治疗的联合应用可使急性脑血栓患者早期血管再通和得到有效的脑保护。
[Objective] To observe the effect of the combined treatment of mild hypothermia and thrombolytic therapy on patients with acute cerebral infarction. [Methods] 22 patients with acute cerebral infarction of control group were given r-tPA intravenously in a dose of 0. 7-0. 8 mg/kg. 18 patients with acute cerebral infarction;of mild hypothermia group received the same thrombolytic therapy and mild hypothermia therapy. [Results] The neurological deficit grade after 7 days of therapy in mild hypothermia group was significantly lower than：that in the control group. The level of inflammatory factors including Lp-PLA2 and hsCRP one week after therapy in mild hypothermia group were significantly lower than those in the control group.[Conclusion] The combined treatment of mild efficacy to patients with acute cerebral infarction. hypothermia and thrombolytic therapy can provide more
出处
《山东医药》
CAS
北大核心
2007年第1期13-14,共2页
Shandong Medical Journal
