摘要
目的探讨阿司匹林在肺血栓栓塞(PTE)中的应用价值。方法取健康中国大耳白兔32只,随机分为对照组和实验、、组。对照组经股静脉输入生理盐水,实验组经股静脉输入自体血栓制备急性PTE模型,其中实验、组在自体血栓栓塞前7d分别每天清晨灌服肠溶阿司匹林4mg/kg和8mg/kg,并动态监测栓塞前后血栓素A2(TXA2)的无活性代谢物血栓素B2(TXB2)和前列环素(PGI2)的无活性代谢物6-酮-前列腺素F1α(6-K-PGF1α)的变化。结果对照组各项指标在栓塞前后无显著性差异(P>0.05)。实验、、组的TXB2和6-K-PGF1α在栓塞发生5min即有升高(P<0.05),4h出现下降趋势,其中实验、组在各时点的值低于实验组(P<0.01),实验组低于实验组(P<0.01)。在栓塞后实验、组的TXB2/6-K-PGF1α(T/P)低于实验组(P<0.01),实验组低于实验组(P<0.01)。结论血管活性因子TXA2和PGI2对肺血栓栓塞早期的肺血流动力学变化有重要影响。阿司匹林对改善肺血栓栓塞早期肺血流动力学的紊乱有一定作用。
Objective： To explore the value of Aspirin for pulmonary thromboembolism. Methods： Thirty two rabbits were randomly divided into 4 groups. Control group： Eight rabbits were injected with saline via femoral vein. Test group （Ⅰ,Ⅱ,Ⅲ）： All rabbits were injected with autologous thrombus via femoral vein. Test group Ⅱ and Ⅲ： Rabbits were given aspirin （4mg/kg and 8mg/kg respectively） orally every morning for 7 days before autologous thrombosis. TXB2 and 6-K-PGF1α were measured before aspirin medication and thrombosis as well as 30 minutes, 1 hour, 2 hours, 4 hours, 24 hours, 3 days and 7 days after thrombosis. Results： There were no significant difference in all parameters between pre-thrombosis and post-thrombosis in the control group（P〉0. 05）. These two parameters in all three test groups increased just 5 minutes after thrombosis （P〈0. 05）and decreased in 4 hours. At every testing point, above-mentioned parameters in test group Ⅰ and Ⅱ were lower than in test group Ⅰ （P〈0.01） ,meanwhile, parameters in test group Ⅱ was higher than in test group Ⅲ （P〈0. 01）. Conclusion, TXA2 and PGI2 are couple of inter-active blood vessel active factors, which have an important influence on pulmonary hemodynamic changes of PTE in early stage. Aspirin can ameliorate severity of pulmonary hemodynamic changes of PTE.
出处
《陕西医学杂志》
CAS
北大核心
2007年第1期25-28,共4页
Shaanxi Medical Journal
关键词
肺栓塞/病理学
肺栓塞/药物疗法
阿司匹林/治疗应用
血栓烷A2/代谢
依前列醇/代谢
动物
实验
兔
Pulmonary embolism/pathology Pulmonary embolism /drug therapyAspirin/ therapeutic use Thromhoxane A~/ metabolism Epoprostenol/ metabolism Animals,laboratory Rabbits
