摘要
放疗增敏作用是提高综合治疗疗效的主要方式。EGFR通路异常激活,酪氨酸激酶(EGFR-TK)活性增强会激活下游信号通路,肿瘤细胞增殖、侵袭、转移和血管生成的生物学特性得到强化,最终促进了肿瘤的发生和进展,且伴有放射抗拒。EGFR靶向抑制剂均具有明确的放射增敏作用,已经在临床中取得了不同程度的成功,并且有望在非小细胞肺癌的治疗中开拓新的领域。
Radiosensitization effect is found to be the major mechanism to achieve prolonged survival in many tumors treated by combined chemo-radiation therapy. EGFR is expressed in many normal human tissues, and activation of this proto-oncogene results in overexpression in many types of human tumors. The enhanced activity of the EGFR-TK could contribute to tumorigenesis and tumor progression through the promotion of tumor cell proliferation, survival, invasiveness, and metastasis, as well as through increased angiogenesis. Signal transduction through the EGFR-TK activates several pathways that are thought to contribute to radiation resistance, including cell cycle alterations, decreased apoptosis, and enhanced proliferation. There is considerable evidence that EGFR inhibitors confer a profound radiosensitization effect. EGFR inhibitors have been tested as a radiosensitizer with radiotherapy intensively. Hopefully, this strategy will expand horizon in NSCLC treatment.
出处
《中国癌症杂志》
CAS
CSCD
2007年第1期32-36,共5页
China Oncology
