摘要
背景与目的骨外软组织Ewing肉瘤是临床上十分罕见的高度恶性肿瘤,报告2例病例并探讨其临床病理学特征。方法运用光镜和电镜观察、组织化学及免疫组化染色方法,并复习以往相关文献。结果骨外软组织Ewing肉瘤瘤细胞呈小圆形,异型性明显,较少或无菊形团(Homer-wright)结构。PAS特殊染色胞质中大量阳性细小颗粒沉积。免疫组化CD99(MIC2)和Vimentin标记呈强阳性表达。电镜观察可见瘤细胞质内有少量神经内分泌颗粒及丰富的糖原颗粒分布。结论骨外软组织Ewing肉瘤是Ewing/pPNET家族肿瘤的一个亚型。骨外软组织Ewing肉瘤具有高度恶性、易复发和转移的临床特点,若出现神经分化的特点可能是具有更高侵袭性和不良预后的标志。
Background and purpose： Ewing＇s sarcoma of soft tissue is a rare and highly malignant tumor. In our paper, 2 cases are reported in order to investigate the clinic and pathologic features. Methods： The two cases of Ewing＇s sarcoma of soft tissue were studied by HE staining, histochemistry, immunohistochemistry, light microscopy and electron microscopy. The related literature also has been reviewed and current status of the study on the disease was included in the paper. Results： Microscopically, Ewing＇s sarcoma of soft tissue is composed of small round ceils with high atypia, and rare or no Homer-wright rosette structures could be observed. PAS staining showed that a great mount of small positive granules were located in the cytoplasm of tumor ceils. CD99 （MIC2） and Vimentin were strongly expressed in all the tumor ceils. Ultrastructural studies showed that some neuroendocrine and much glycogen granules were distributed in cytoplasm of the tumor cells. Conclusions： Ewing＇s sarcoma of soft tissue was one of the subgroups of Ewing/pPNET family that had the highly invasive features. Local relapse and metastases are often observed after the treatment. Neural differentiation of the ceils might pathologically be the predictive sign of poor prognosis and of high infiltration ability.
出处
《中国癌症杂志》
CAS
CSCD
2007年第1期54-57,共4页
China Oncology
关键词
PNET
EWING肉瘤
免疫组化
超微结构
PNET
Ewing＇ s sarcoma of soft tissue
ultrastructure
immunohistochemistry
