摘要
目的:揭示清开灵防治化学性肺水肿的有效成分及可能的作用机制。方法:雄性ICR小鼠随机分组,全氟异丁烯(PFIB)动态吸入染毒后1 h分别腹腔注射清开灵的4个部位和全方,观察染毒后24 h肺系数等指标变化。结果:①清开灵对抗PFIB所致肺水肿作用的有效部位是总胆酸组分。②清开灵方中非胆酸组分对总胆酸组分无促进协同作用。总胆酸组分中以猪胆酸的效果稍强,与牛胆酸配伍后,无相互协同作用。③PFIB吸入肺水肿发生机制与二甲苯致炎机制不同,表现为糖皮质激素可有效抑制二甲苯致炎作用,但无对抗PFIB肺水肿作用,说明在化学性肺水肿的治疗中,清开灵具有非激素样的独特的作用机制。④这种独特的作用机制可能与表面活性作用相关。结论:清开灵的作用机制可能与胆酸的表面活性作用有关。
Objective： To unveil the effective ingredients and mechanisms of Qingkailing injection on the treatment of pulmonary edema induced by chemicals. Method： Mice were exposed to perfluoro sobutylene（PFIB） in a flow-pass chamber, the lung index after 24 h were determined. Result： ① The part of total cholic acid played a pivotal role; ② The parts of non-cholic acid had no cooperative effects to the part of cholic acid if co-administration. In the part of total cholic acid, the efficiency of hyodeoxylcholic acid was better than that of cholic acid; ③ Qingkailing injection would have special mechanism different from corticosteroid, which has no effect against PFIB but dimethylbenzene; ④ The special effects of cholic acid maybe result from its surfactant effects. Conclusion： The mechanism of Qingkailing injection may be related to the cholic acid due to its surfactant effects.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2007年第1期53-57,共5页
China Journal of Chinese Materia Medica
关键词
肺水肿
清开灵
胆酸
表面活性剂
pulmonary edema
Qingkailing
cholic acid
surfactant
