摘要
系统性红斑狼疮(SLE)是一种自身免疫性疾病,患者血清中可检出多种自身抗体,但抗Sm ith(Sm)抗体是SLE的标记性抗体。作者就Sm抗原的理化特性、生物学作用和抗Sm抗体的检测作一综述。
Systemic lupus erythematosus （SLE） is an autoimmune disease characterized by the production of autoantibodies against a wide spectrum of nuclear, cytoplasmic, and cell membrane autoantigens. Among them, the anti-Smith antibodies are specific for SLE and thus have been included as a criteria for diagnosis. They are not only a diagnostic marker but also a reliable measure of disease activity in SLE, we intend to describe the biological functions and clinical significance of the Smith antigen and the detection of anti-Smith antibodies.
出处
《医学研究生学报》
CAS
2007年第1期90-93,共4页
Journal of Medical Postgraduates
基金
福建省青年科技人才创新项目基金资助(批准号:2002J060)
关键词
系统性红斑狼疮
Smith抗原
理化特性
生物学作用
Systemic lupus erythematosus
The Smith antigen
Characterization
Biological functions
