摘要
目的：探讨视网膜神经上皮层同种异体移植的可能性。方法：用新生小鼠的视网膜神经上皮层组织块移植到３６只成年小鼠的视网膜下间隙，分别于手术后６、１２、１８天各处死受鼠１２只，摘取眼球做光镜病理组织学检查。结果：１６．７％（６／３６）受鼠眼球未找到移植物，其自身组织完整无损；６６．７％（２４／８６）移植物存活于视网膜下间隙或视网膜内层；８．３％（３／３６）存活于玻璃体腔内，皆分化发育形成花环结构；８．３％（３／３６）发生毁坏性肉芽肿性炎症。结论：在我们１８天的观察时间内，移植物成功植入的３０只眼标本中９０．０％（２７／３０）的移植物存活，并进一步分化和发育。
OBJECTIVE:Toexaminethepossibilityofalogenicneuralretinaltransplantation.METHODS:Donorneuralretinaltissueobtainedfromneonatalmicewasimplantedintothesubreti-nalspaceof36adultmice.Twelverecipientsweresacrificedatday6,day12,andday18post-trans-plantationrespectively,andtheeyeswereenucleatedforhistologicexamination.RESULTS:Thegraftwasfailedtobefoundbutthehostretinaremainednormalin16.7%(6/36),thegraftwasfoundsurvivalandshowedfurtherdiferentiationintoroseteformationinthehostsubretinalspaceandinnerretinain66.7%(24/36),inthevitreouscavityin8.3%(3/36).Disastrousgranulomatousinflammationoccuredin8.3%(3/36).CONCLUSION:Alogenicretinafromneonatalmiceimplant-edintothesubretinalspacemightexperienceimmuneprivilege,inagreatextent,andshowedfurtherdiferentiationduringtheexperimentalperiodsoftime.
出处
《中华眼底病杂志》
CAS
CSCD
1996年第4期236-238,共3页
Chinese Journal of Ocular Fundus Diseases
关键词
视网膜移植
同种移植
异体移植
Retina/transplantationTransplantation,homologousMice
