摘要
目的探讨宫颈癌组织中P-糖蛋白(P-gp)、谷胱甘肽S-转移酶-π(GST-π)和胸苷酸合成酶(TS)的表达及临床意义。方法采用免疫组化方法检测51例宫颈癌组织及9例正常宫颈组织中P-gp、GST-π和TS蛋白的表达情况。结果9例正常宫颈组织中,P-gp、TS蛋白均不表达,GST-π蛋白高表达4例(44.44%)。51例宫颈癌组织中,P-gp、GST-π和TS蛋白表达率分别为45.10%、62.75%和43.14%。宫颈癌组织中P-gp、TS蛋白的表达率高于正常组织(P<0.05)。宫颈癌中P-gp和GST-π蛋白共表达率为29.41%,GST-π和TS蛋白共表达率为29.41%,P-gp和TS蛋白共表达率为19.61%,3种耐药蛋白共表达率为13.73%。P-gp、GST-π和TS蛋白表达与宫颈癌组织分化和临床分期均不相关(P>0.05)。结论P-gp、GST-π和TS蛋白表达可能在宫颈癌的原发性多药耐药起重要作用。
Objective ：To investigate the expression of P-gp, GST-π and TS protein in primary cervical cancer and their clinical significance. Methods：Consecutive sections from 51 cases of cervical cancer and 9 normal cervical tissues were assessed immunohistochemically for expression of P-gp, GST-π and TS protein. Results： P-gp and TS protein were not detectable in normal cervical tissues. High expression of GST-π protein was observed in 4 （44.44%） of 9 normal cervical tissues. Positive expression of P-gp protein was observed in 23 （45. 10% ）, high expression of GST-π protein in 32 （62.75%）, and TS protein in 22 （43. 14% ） of the 51 tumors, respectively. The expression of P-gp and TS proteins in cervical cancer was significantly higher than that in normal cervical tissues （ P 〈 0. 05 ）. The co-expression rate of P-gp and GST-π protein was 29.41%, of P-gp and TS protein was 29.41% , of GST-π and TS protein was 19. 61%, of P-gp, GST-π and TS protein was 13.73% in cervical cancer. No significant association was found between the expression P-gp, GST-π or TS protein and clinicopathologic feature such as cell differentiation and clinical stage （P 〉 0. 05）. Conclusion：The expression of P-gp, GST-π and TS protein probably play important roles in the primary multidrug resistant （MDR） of cervical cancer.
出处
《临床肿瘤学杂志》
CAS
2007年第1期23-26,共4页
Chinese Clinical Oncology
基金
江西省卫生厅科技基金(031024)
关键词
宫颈肿瘤
P-糖蛋白
谷胱甘肽S-转移酶-Π
胸苷酸合成酶
免疫组化
Cervical cancer
P-glycoprotein （ P-gp ）
Glutathione -transferase-π （ GST-π ）
Thymidytate synthase （TS）
lmmunohistochemistry
