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细胞内低氧感受器:缺氧诱导因子-1脯氨酰羟化酶研究进展 被引量：13

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摘要 哺乳动物细胞对低氧的适应性调节是通过改变一系列基因表达来实现的。调控这些基因表达最重要的转录因子是缺氧诱导因子-1(HIF-1),而能够直接感受氧分压、作为氧感受器的一种双加氧酶——脯氨酰羟化酶(PHD)则是调节HIF-1的关键分子。常氧状况下,HIF-1α的两个关键氨基酸残基Pro402和Pro564被PHD羟基化进而被蛋白酶水解,此时细胞内无HIF-1聚集,形成一种氧分压正常的信号状态。低氧状况下,PHD羟基化HIF-1α反应受阻,HIF-1聚集并入核诱导多种靶基因表达,启动低氧应答反应。本文就PHDs家族如何调控HIF-1α及PHD的调节剂研究进展进行综述。
作者 李佩尧 张成岗
机构地区 军事医学科学院放射与辐射医学研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2007年第1期62-65,共4页 Progress in Physiological Sciences
基金 国家重点基础研究发展计划(973计划)(2003CB715900 2006CB504100) 国家自然科学基金(30400465 30300358 90208017) 北京市自然科学基金重点项目(7061004) 北京市科技新星计划A类(2005A44)资助课题
关键词 脯氨酰羟化酶 缺氧诱导因子-1 氧感知
分类号 Q291 [生物学—细胞生物学]
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参考文献10

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二级参考文献10

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生理科学进展
2007年 第1期

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