摘要
目的 探讨内皮素能否引起肺水肿，以及其发生的机理。方法采用不同剂量的内皮素-１（ＥＴ－１）加入含白蛋白的平衡盐灌流液中灌流大鼠离体肺的方法，观察了灌流前后肺重量，肺血管压力、阻力和肺血管通透性［溶解速度（Ｋｆ）和溶解指数（Ｐ３）］的变化。结果小剂量ＥＴ－１灌流后，肺增重０．１８３±０．０５ｇ，每克鼠肺每分钟Ｋｆ为０．３６±０．０５ｍｌ／ｋＰａ，明显高于正常对照组。其它参数无明显变化。大剂量ＥＴ－１灌流后，肺增重０．２３±０．０４ｇ，灌流前后肺动脉压差值０．４２±０．１７ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ），肺血管后阻力差值０．１０±０．０１ｋＰａ，肺血管总阻力差值为０．２２±０．０６ｋＰａ，均明显高于正常对照组，而Ｋｆ和Ｐｓ则正常。结论用ＥＴ－１灌流鼠肺能够引起肺水肿。ＥＴ－１导致肺水肿的机理随剂量大小而有所不同，小剂量使肺毛细血管壁对小分子的通透性增加；而大剂量则与毛细血管跨壁压增高有关。
Objective To investigate the machanisms of ET-1-induced lung edema. Methods Different doses of ET- 1 were added to isolate rat lungs perfused by Ringer' s solution containing albumin to explore the mechanisms of ET-1 induced pulmonary edema. The lung weight gain , pulmonary vascular permeabilityto water (Wf ) and albumin (Ps ) were observed. Results lt was found that low daoe ET-1 increased lung weight gain , pulmonary artery pressure , pulmonary capillary pressure , pulmonary vascular post-re- sistance and total resistance , but no significant changes of vascular permeability were observed. Concl u- ston The mechanisms of lung edema induced by ET-1 are different. Low dose ET-1 may induce lung edema by increasing pulmonary vascular permeability while large dose ET-1 by increasing pulmonary vascular p ressure .
出处
《中华医学杂志》
CAS
CSCD
北大核心
1996年第9期694-696,共3页
National Medical Journal of China
关键词
内皮素
肺水肿
病因学
Endothelin Lung edema Animals
experimental
