摘要
作者报告３例骨内发生的恶性化学感受器瘤（恶性化感瘤），均发生在股骨内。临床有疼痛，功能障碍，病理性骨折。Ｘ线表现为囊样透亮含淡条影状的骨质破坏区，骨皮质膨胀变薄呈蛋壳状，无骨膜反应及钙化征象。光镜下瘤细胞呈实性巢索状腺泡样或称“器官样”排列，腺泡间由闭锁或扩张成血窦的薄壁血管和少量纤维组织包绕。嗜银染色瘤细胞均在纤维膜外，瘤细胞不产生网状纤维。随访３例于术后１２、１３、１５个月均因广泛转移而死亡。骨内化感瘤虽有细胞分化高低之分，但其生物学行为均表现为恶性。
Theauthorsreported3casesofmalignantchemodectomaofbone.Theageofthepa-tientsatsurgerywere41,33and59.Althetumorswerelocatedinsidethefemurwithoutrelationtothefemoralartery.Theclinicalmanifestationswerepain,lossoffunctionandpathologicalfractureofthefemurX-rayfilmsshowedbonedestructiongivingcysticandtransparentappearance,Thebonecortexwasexpandedandthinned,egg-sheledwithoutperiostealreactionorcalcification.Undermicro-scope,thetumorcelsweresolid,nest-likeorcord-likeassumingtheso-caled'organoidarrangememt'.Theywerepolygonalorepitheloid,richincytoplasm,withthickorthingranules.Thenuclearmem-branesandthenucleolicouldbeclearlyseen.Afewkaryokineticphasesofthemononuclearandmultin-ucleargiantcelscouldalsobeseen.Vimentin:1:5,keratin1:300,CEA1:100,Factor(vdAWF:Ag)stainningwithimmunohistochemicalmethod(ABC)chromafinandPASstainningwerenegative.Altheargentafinoncocyteswerebesidethefibrorscels.Theresultsconfirmedthatthetumorsareprima-rychemodectomasofbone.Althe3patientsdiedofextensivemetastasis,12,13,and15monthsaftersurgery.Theauthorsconcludedthatthebiologicalbehaviorofchemodectomasofboneismalignantnomaterhowwelorhowpoorthestatusoftheirdifferentiation.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1996年第11期687-689,共3页
Chinese Journal of Orthopaedics
