摘要
选择环境氟水平相同硒水平不同的地方性氟中毒区进行环境氟、硒含量、人群氟、硒中毒以及血清中超氧歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）水平等项调查。结果表明高硒临界水平调查点居民氟中毒、硒中毒检出率明显高于正常硒水平调查点的居民（Ｐ＜０．０５），且居民尿氟、血硒明显增加（Ｐ＜０．００１），血清中ＳＯＤ值明显下降（Ｐ＜０．００１），ＭＤＡ值明显增高（Ｐ＜０．０５）。提示高硒高氟可使机体内超氧歧化酶活性下降，脂质过氧化作用增强，从而加重了氟、硒中毒程度。
luoride (F) and selenium (Se) content in the environment, the incidences of fluorosis and selenosis, the levels of SOD and MDA were investigated in the endemic fluorsis areas with similar concent of F and different concent of Se. It was found that the incidences of fluorosis and selenosis and the urinary F and serum MDA of the residents living in the high Se area were much higher and serum SOD lower than that of the residents living in the normal Se area. The results showed that the toxic degrees of the fluorosis and selenosis were much more serious with the decrease of SOD and the increase of MDA. In other words, a synergic effect of F and Se on human health was found in the with high F and high Se environment.
出处
《卫生研究》
CAS
CSCD
北大核心
1996年第5期287-290,共4页
Journal of Hygiene Research
基金
国家自然科学基金资助项目
关键词
硒中毒
氟中毒
selenium
fluoride
selenosis
fluorosis
