摘要
【目的】评价左氧氟沙星单次给药治疗老年细菌性下呼吸道感染的有效性和安全性。【方法】细菌性下呼吸道感染的老年病人70例，采取随机、开放、对照研究方法，观察组（n=35）采取每日静脉滴注左氧氟沙星注射液0．5g／次，1次滴注；对照组（n=35）采取每日静脉滴注左氧氟沙星注射液0．2g／次，每日2次滴注。治疗7～14d后评价疗效。【结果】59例进入最后临床疗效分析，观察组临床痊愈率和有效率分别为75．9％、86．2％。与对照组70．0％、80．0％比较差异无显著性（P〉0．05）；观察组细菌清除率为90．9％（20／22），明显高于对照组66．7％（16／24）（P〈0．05）；两组不良反应发生率分别为16．6％（5／30）和21．8％（7／32），差异无显著性（P〉0．05）。【结论】左氧氟沙星单剂量治疗老年细菌性下呼吸道感染安全有效。
[Abstract][Objective]To evaluate the efficacy and safety of intravenous levofloxacin once-daily for treat- ment of lower respiratory tract bacterial infections of the elderly patients. Sixty - eight patients were divided into two groups, in a randomized ,open-label, controlled study. Patients were treated with intravenous levofloxacin 0.5g once daily in observation group （ n = 35）. Intravenous levofloxacin 0.2g was given twice daily in control group （ n =35 ）. The duration of treatment was 7～14 days in both groups, The primary efficacy parameter was clinical and bacteriological response at the end of treatment in the evaluable patients. [Results] Fifty nine patients were eligible for clinical efficacy analysis , 30 in observation group＇,and 29 in control group. The cure rates and effective rates were 75.9% and 86.2% in observation group ,and 70. 0% and 80. 0% in control group respectively , there were no statistically significant difference between the two groups（ P 〉0. 05）. The bacterial eradication rates were 90. 9% （20/22） and 66.7% （16/24）respectively, there was statistically significant difference between the two groups（ P〈0.05）. The incidence of adverse reactions was 16.6% （5/30） and 21.8% （7/32） respectively, there was no statistically significant difference between the two groups （ P 〉0.05）. [Conclusion]The regimen of levofloxacin 0.5 g once daily is effective and safe for the treatment of the lower respiratory tract bacterial infections in the elderly patients.
出处
《医学临床研究》
CAS
2007年第1期39-42,共4页
Journal of Clinical Research
