摘要
目的:了解海拔4 250m地区高原人群血清EPO(红细胞生长素)、T(睾酮)、E2(雌二醇)含量变化与HAPC(高原红细胞增多症High AltitudePolycythemia,HAPC)的相关关系。方法:在海拔4 250m地区筛选出HAPC,且测定了世居高原藏族、移居高原汉族、高原红细胞增多症患者三组人群血清中EPO、T、E2含量。结果:HAPC组:移居高原汉族18人(占66.66%),世居高原藏族9人(占33.33%),男女比例为26:1,三组间EPO差别无显著性,P>0.05,但是高原人群血清中的EPO含量高于平原地区3.788倍。三组间T、E2差别无显著性,P>0.05,T在高原红细胞增多症、世居高原藏族和移居高原汉族三组间差别无明显性,但是T低于平原地区8.43倍。可能与高原人群T的活性增加有关,在今后的工作做进一步调查。结论:EPO、T、E2与HAPC的发病虽然无直接因果关系,但是EPO含量高于平原人群3.788倍,T含量明显低于平原人群8.43倍,EPO的增高和T的降低是一种高原人群的生理病理特征表现。
Objective. To study the changes of serum level of T, E2 and EPO in various populations at high altitude. Methods： We had selected the patients with HAPC at 4 250m altitudes in this study. All subjects were designed in the Tibet nativegroup, the Han migrate group and the HAPC group. The serum level of T,E2 and EPO were measured by RIA. Results： There was a significant difference between the migrate group （n=18, 66.66%） and the native group （n=9, 33.33%） in the HAPC. No difference of T and E2 among the three groups but level of T lowed 8. 43-fold in high altitude in compared to the plain subjects. No difference of level of EPO among the three groups, but the level of EPO increased 3. 788--[old in high altitude populations in compared to plain group. Conclusions： There is no a directive active correlation between changes of EPO, T and E2 and HAPC but that in plain; in contrast to the level of T. the level of EPO is higher in high altitude people than that in plain; in contrast to the level of T.
出处
《高原医学杂志》
CAS
2006年第4期19-21,共3页
Journal of High Altitude Medicine
关键词
高原红细胞增多症
红细胞生长素
睾酮
雌二醇
High altitude
Testo（T）
Estradiol （E）
Sex hormone
Native
Migration
Han
Tibet
