摘要
目的:探讨血管内皮生长因子-C(vascularendothelialgrowthfactorC,VEGF-C)在乳腺癌组织的表达情况及与临床病理指标的关系。方法:应用免疫组织化学方法检测69例乳腺癌和10例乳腺纤维腺瘤组织的VEGF-C表达情况,并分析其表达与临床病理特征的关系。结果:69例乳腺癌组织中VEGF-C阳性表达72.46%(50/69),10例乳腺纤维腺瘤表达为30%,两者差异有统计学意义(Hc=10.173,P<0.01)。VEGF-C在乳腺癌中的表达与其组织学分级有关(χ2=12.026,P<0.01),组织学分化Ⅲ级的VEGF-C阳性表达率为92.86%,高于组织学分化Ⅰ级(37.5%,P<0.01)、Ⅱ级(63.64%,P<0.05),Ⅰ级与Ⅱ级比较差异无统计学意义(P>0.05);有腋淋巴结癌转移组与无转移组的VEGF-C阳性表达率分别为87.10%和60.53%,差异有统计学意义(P<0.05);而与月经状态、肿瘤大小、病理类型、TNM分期、ER/PR状态和预后无关(均P>0.05)。结论:乳腺癌组织中VEGF-C的表达明显增加,其表达水平显著高于乳腺纤维腺瘤,并且与肿瘤组织学分级、区域淋巴结转移有关。
Objective： To investigate the expression of VEGF-C （vascular endothelial growth factor C） in human breast cancer and evaluate their clinical significance. Methods： Immunohistochemical staining was performed to examine the expression of VEGF-C in sixty-nine cases of breast cancer and ten breast fibroadenoma tissues and analyzed relationship between the expression of VEGF-C and the clinical pathological features. Results： Positive expression of VEGF-C in all sixtynine cases of breast cancer （72.46%, 50/69） was higher than those in ten fibroadenoma tissues （30%）, the difference had statistical significance （Hc=10.173, P 〈 0.01）. There was a significant relationship between the expression of VEGF-C and the histological grade in breast cancer （χ^2 = 12.026, P 〈 0.01） and the positive expression of VEGF-C in grading Ⅲ （92.86%） was higher than those in grading Ⅱ （63.64%, P 〈 0.05）and grading Ⅰ （37.5%, P 〈 0.01）. No significance was found between grading Ⅱ and grading Ⅰ （P 〉 0.05）. The positive expression of VEGF-C in those with metastatic axillary lymph node （87.10%） was higher than those without metastatic （60.53%）, the difference had statistical significance（P 〈 0.05） and no relationships were related with the menstruation status, tumor size, histological type, TNM stage, EP/PR and prognosis （P 〉 0.05）. Conclusion： The expression of VEGF-C increase in breast cancer and is significantly higher than those in the breast fibroadenoma ,moreover, it is associated with grading and metastasis in axillary lymph node.
出处
《天津医药》
CAS
北大核心
2007年第1期12-14,共3页
Tianjin Medical Journal
基金
河北省科技厅科技攻关项目(项目编号:0527611D57)
关键词
乳腺肿瘤
纤维瘤
血管内皮生长因子C
免疫组织化学
breast neoplasm fibroma vascular endothelial growth factor C immunohistochemistry
