摘要
目的综述近年来有关胚胎干细胞(embryonic stem cell,ESC)自我更新相关的信号转导途径及体外培养系统的研究进展。方法广泛查阅近年有关ESC自我更新相关的信号转导途径及体外培养研究的文献,并进行综述。结果阐明有关ESC体外自我更新和多向分化潜能的分子机制,有助于改善ESC体外培养系统条件,是ESC成功应用于临床的基础。结论有关ESC实现自我更新及多向分化潜能的分子信号尚需更多研究,ESC培养体系有待于进一步完善和发展。
Objective To review the latest development and culture system in vitro of the embryonic stern cells （ESCs）. of the research on the self-renwal signaling pathway Methods The recent articles about the self-renewal signaling pathway and culture system in vitro of the ESCs were extensively reviewed. Results Understanding of the molecular mechanism of the self-renewal in vitro and pluripotency of the ESCs was considered important for developing improved methods of deriving, culturing and differentiating these cells into the cells that could be successfully used in the clinical practice. Conclusion A further research is needed to elucidate the self-renewal signaling pathway and the pluripotency of the ESCs and the culture system in vitro for the human ESCs remains to be further improved and developed.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2007年第2期188-193,共6页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
胚胎干细胞
自我更新
信号转导
培养系统
Embryonic stem cells Self-renewal Signaling pathway Culture system
