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持续气道正压通气对合并2型糖尿病的OSAHS患者胰岛素抵抗的影响 被引量：8

Effects of continuous positive airway pressure treatment on insulin resistance in patients with type 2 diabetes and obstructive sleep apnea hypopnea syndrome
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摘要 目的:通过观察了持续气道正压通气(CPAP)治疗对合并2型-糖尿病(2型-DM)的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的胰岛素抵抗(IR)的影响,以验证OSAHS是否为引起糖尿病患者IR增加的独立危险因素。方法:选择25例合并2型-DM的肥胖OSAHS患者,将他们的呼吸暂停/低通气指数(AHI)为37.7±18.0;体重指数(BMI)被控制在29.1±2.3kg/m2;通过6个月的CPAP治疗观察治疗前后反映IR的稳态模式评估(HOMA)指数变化。结果:在BMI无明显改变的情况下,6个月的CPAP治疗后HOMA指数较治疗前明显降低(1.84±1.98vs3.33±2.96,P<0.0001)。结论:CPAP治疗可显著改善OSAHS患者的IR增高,提示OSAHS是IR的独立危险因素。 Objective： To investigate the effects of continuous positive airway pressure （CPAP） treatment on insulin resistance （IR） in patients with type 2 diabetes and obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods：Twenty-five patients with type 2 diabetes and OSAHS were recruited. Their apnea hypopnea index （AHI） was 37.7±18.0 with BMI maintained at 29.1 ± 2.3 kg/m^2. The homeostasis model assessment （HOMA） index was used to reflect IR and measured before and after 6 months＇ CPAP treatment. Results：The HOMA index was significantly lower following 6 months＇ CPAP treatment than before treatment （ 1.84 ± 1.98 vs 3.33 ± 2.96, P 〈 0.0001）. Conclusion：CPAP treatment can significantly improved increased IR in OSAHS patients, which suggests that OSAS is an independent risk factor of IR.
作者 黄晶晶 李翀 张希龙
机构地区 南京医科大学第一附属医院呼吸内科
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2007年第1期39-42,共4页 Journal of Nanjing Medical University(Natural Sciences)
关键词 阻塞性睡眠呼吸暂停低通气综合征 持续气道正压通气 胰岛素抵抗 2型糖尿病 obstructive sleep apnea hypopnea syndrome continuous positive airway pressure insulin resistance type 2 diabetes
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献12

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二级参考文献13

  • 1刘辉国,刘瑾,熊盛道,沈关心,张珍祥,徐永健.The Change of Interleukin-6 and Tumor Necrosis Factor in Patients with Obstructive Sleep Apnea Syndrome[J].Journal of Huazhong University of Science and Technology(Medical Sciences),2000,20(3):200-202. 被引量：22
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共引文献40

同被引文献144

引证文献8

二级引证文献16

南京医科大学学报（自然科学版）
2007年 第1期

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