摘要
为探讨2型糖尿病合并高血压患者抵抗素与动脉粥样硬化(AS)的相关性,用彩色多普勒超声技术观察2型糖尿病(A组)29例患者,2型糖尿病合并高血压(B组)23例患者及20名对照组的颈动脉内中膜厚度(IMT)及斑块的变化;应用ELISA测定血浆抵抗素水平。结果表明:A组和B组抵抗素水平较对照组显著升高(P<0.01),且B组抵抗素较A组显著升高(P<0.05);抵抗素与IMT、SBP、FBG、HOMA-IR显著正相关,与FINS显著负相关;IMT与抵抗素、年龄、BMI、SBP、FBG、FINS、HbA1c、HOMA-IR显著正相关。本文提示抵抗素参与胰岛素抵抗(IR),在AS发生及发展中起着重要作用。
To study relationship between plasma levels of resistin with atherosclerosis in type 2 diabetes mellitus（T-2 DM） complicated hypertension, Color Doppler ultrasound was used to measure the intima-media thickness（IMT） and plaque of the common carotid artery in 29 T-2 DM alone,and 23 T- 2 DM complicated hypertension, and 20 health controls. Fasting plasma resistin was measured by ELISA. Results showed that plasma levels of resistin in those groups of T-2 DM were significantly higher than that in health control（P〈0.01） ,and levels of resistin in T-2 DM complicated hypertension were significantly higher than that in I- 2 DM alone; bivariste correlative analysis showed that the resistin level was significantly correlated with SBP, FBG ,IMT and HOMA-IR,and was negatively correlated with FINS; Bivariste correlative analysis showed that IMT was significantly correlated with resistin, age, BMI,SBP, FBG, FINS, HbA1c, HOMA-IR . The levels of resistin were higher in the patients of T- 2 DM,and the resistin levels in T- 2 DM complicated hypertension were significantly higher than that in T- 2 DM alone. Resistin was involved in insulin resistance （IR） ,and played pivotal roles in the pathogenesis and development of atherosclerosis.
出处
《标记免疫分析与临床》
CAS
2006年第4期215-217,共3页
Labeled Immunoassays and Clinical Medicine
关键词
抵抗素
糖尿病
动脉粥样硬化
高血压
Resistin
Diabetes mellitus
Atherosclerosis
Hypertention
