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Y染色体微缺失与男性不育 被引量：19

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摘要 遗传因素导致的生精障碍是引起男性不育的一个重要原因,研究发现,Y染色体长臂上无精子因子(AZF)的缺失可以导致男性生精障碍,大多表现为无精或严重少弱精。在特发性无精症、隐睾和精索静脉曲张的不育患者中均已检测到AZF的缺失。胞浆内单精子注射(ICSI)在解决男性不育问题的同时,也有可能将父代的遗传缺陷传递给男性后代,所以对无精症及严重少弱精症患者尤其是行ICSI助孕的不育男性有必要常规行AZF缺失的检测。现就Y染色体AZF微缺失的机制、与特发性男性不育及睾丸病变的关系、微缺失检测的临床意义等方面进行综述。
作者 项云改 谭丽
机构地区 郑州大学第二附属医院生殖研究室
出处 《国外医学（计划生育．生殖健康分册）》 CAS 2007年第1期5-8,共4页
关键词 无精子症 Y染色体微缺失 AZF因子 生精障碍
分类号 R698.2 [医药卫生—泌尿科学]
  • 相关文献

参考文献20

  • 1Dohle GR, Halley DJ, Van Hemel JO, et al. Genetic risk factors in infertile men with severe oligzoospermia and azoospermia [J]. Hum Reprod,2002,1 (17) : 13-16.
  • 2Tessari A, Salata E, Ferlin A, et al. Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis [ J ]. Mol Hum Reprod,2004,10 ( 4 ) : 253-258.
  • 3Kinoshita K, Shinka T, Sato Y, et al. Expression analysis of a mouse orthologue of HSFY, a candidate for the azoospermic factor on the human Y chromosome[J]. J Med Invest,2006,53 (1-2) : 117-122.
  • 4Hucklenbroick K, Gromoll J, Heinrich M, et ai.Partial delefions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesis [J]. Hum Reprod,2005,20( 1 ) : 191- 197.
  • 5Kunej T, Zorn B, Peterlin B. Y chromosome microdeletions in infertile men with cryptorchidism [J]. Fertil Steril,2003,79 [Suppl 3 ] :S1559-1565.
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  • 7Rima Dada,N.P. Gupta,K. Kucheria.AZF microdeletions associated with idiopathic and non idiopathic cases with cryptorchidism and varicocele[J].Asian Journal of Andrology,2002,4(4):259-263. 被引量：22
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二级参考文献12

  • 1J. Selva,S. Kanafani,Y. Prigent,V. Poncet,M. Bergère.Incidence of AZF (Azoospermia Factor) Deletions and Familial Forms of Infertility Among Patients Requiring Intracytoplasmic Spermatozoa Injection (ICSI)[J].Journal of Assisted Reproduction and Genetics.1997(10)
  • 2L. Tiepolo,Orsetta Zuffardi.Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human y chromosome long arm[J].Human Genetics.1976(2)
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  • 5Vogt PH,Edelmann A,Kirsch S,Henegariu O,Hirschmann P,Kiesewetter F,et al.Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq 11[].Human Molecular Genetics.1996
  • 6De Kretser DM.Male infertility[].The Lancet.1997
  • 7Vogel T,Speed RM,Teague P.Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazll null background mimic a human azoospermic factor phenotype[].Human Reproduction.1999
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  • 9Chang LP,Saver VM,Brown S.Y chromosome microdeletion in a father and his four sons[].Human Reproduction.1999
  • 10Moro E,MarinP,Rossi A,Garolla A,Ferlin A.Y chromosome Microdeletion in infertile men with Varicocele[].Molecular and Cellular Endocrinology.2000

共引文献21

同被引文献138

引证文献19

二级引证文献69

国外医学（计划生育．生殖健康分册）
2007年 第1期

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