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左炔诺孕酮宫内缓释系统与子宫内膜突破性出血 被引量:14

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摘要 左炔诺孕酮宫内缓释系统是一种安全、高效的宫内节育器,近年来还被用于治疗月经过多等妇科疾病并取得较好的效果,但其主要不良反应即子宫内膜的不规则突破性出血至今仍未妥善解决。近年研究表明,子宫内膜血管结构和功能的异常是左炔诺孕酮宫内缓释系统引起不规则出血的原因,而与子宫内膜血管生成和血管稳定性有关的各种因子的改变是其分子生物学基础,现就此作一综述。
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