摘要
目的:观察比较低剂量氯胺酮联合吗啡组与单纯吗啡组硬膜外自控镇痛术(PCEA)用于晚期癌痛的效果。方法:选择50例晚期癌痛患者,分为联合组和单纯组,分别给予配制100mg氯胺酮,10mg吗啡的100ml镇痛液和单纯20mg吗啡的100ml镇痛液,背景剂量2ml/h,单次按压剂量2ml,锁定时间15min。分别记录1,3,6,12,24,48h的视觉模拟法(VAS)评分及不良反应,并运用汉密顿抑郁量表(HAMD)进行治疗前后的抑郁情绪评估。结果:联合组镇痛效果、抑郁情绪评估优于单纯组,不良反应发生率、按压次数、吗啡用量皆低于单纯组(P<0.05)。结论:低剂量氯胺酮联合吗啡硬膜外自控镇痛术在镇痛效果、减少吗啡用量、降低不良反应、改善患者生活质量方面效果明显。
Objective： To compare the analgesic effect of a small dose of ketamine combined with morphine with that of simple morphine for PCEA with advanced cancer. Methods： 50 patients with advanced cancer were divided into two groups, separately received 100mg ketamine , 10mg morphine in 100ml analgesic liquid and simple 20mg morphine in 100ml analgesic liquid, background dose of 2ml/h,2ml was given each press in 15 mins. The scores of VAS and the bad reaction in the course of 1 , 3, 6, 12, 24 and 48 hours were recorded and the depressed emotion before and after treatment was evaluated with HAMD. Results： The effect of the combined group was better than that of simple group, the incidence of the bad reaction, the number of the press,and the dose of morphine in the former were lower than that in the latter（P〈0. 05）. Conclusion. The effect of a small dose of ketamine combined with morphine is better in relieving pain and improving the living quality of the patients.
出处
《医学理论与实践》
2007年第2期135-136,共2页
The Journal of Medical Theory and Practice
