摘要
慢性阻塞性肺疾病急性加重（AECOPD）导致肺功能迅速下降。其发生机制仍不十分清楚，先后经历了黏液嵌塞假说、气道高反应学说、感染学说、细菌负荷周值理论和肺组织损伤加剧等认识过程，目前认为可能是多种因素综合作用的结果，其中一种或多种因素可能是发生AECOPD的触发因素。因此，深入了解该病机制有助于延缓甚至或阻断COPD进程。
Acute exacerbation of chronic obstructive pulmonary disease （AECOPD） is related to the rapid decline of lung function. But ifs mechanism is still unclear and there have been several hypothesis about it,such as the ＂british hypothesis＂, the ＂dutch hypothesis＂, the ＂infection theory＂ and the ＂threshold hypothesis＂. Proteases destroy the lung tissue by destructive nature and nondestructive activities. AECOPD is triggered by a variety of factors, including endogenous ones and exogenous ones. Understanding the pathogenesis of AECOPD may help to prevent the progression of this disease.
出处
《国际呼吸杂志》
2007年第3期203-206,共4页
International Journal of Respiration
关键词
慢性阻塞性肺疾病
发病机制
Chronic obstructive pulmonary disease
Mechanism
