摘要
目的观察唑来膦酸联合放疗与单纯药物治疗恶性肿瘤骨转移癌性疼痛的疗效及不良反应。方法40例骨转移瘤患者随机分为A、B两组(各20例)。A组静滴唑来膦酸4 m g;B组静滴唑来膦酸4 m g后局部放疗。结果两组止痛效果比较:A组显效2例,有效12例,无效6例;B组分别为12、7、1例;两组比较,P<0.05。止痛起效时间:A组为(7.2±2.0)d;B组为(3.0±1.2)d;两组比较,P<0.05。两组均无严重不良反应。结论唑来膦酸联合放疗对恶性肿瘤骨转移所致的癌性疼痛具有良好的止痛效果。
[Objective] To evaluate the efficacy and side effect ot＇ zoledronic acid and radiotherapy to relieve pain due to metastatic bone tumours. [Methods] 40 patients with metastatic bone tumours were randomly divided into group A （n = 20） and group B （n = 20）. Group A was treated with zometa （4 rag,iv drip）. Group B was treated by zometa （4 mg,iv drip） and radiotherapy. [Results] The numbers of patients with remarkable effect , effect and no effect after treatment in group A were 2,12,6 cases;but in group B were 12,7,1 cases（ P 〈 0.01） respectively. The average respond times were （7.2± 2.0）days in group A,and （3. 0±1.2）days in group B （ P 〈 0.05） respectively. The side effect was not serious in two groups. [Conclusion] Zometa can remit metastatic ostealgia effectively,zometa combined with radiation will be better. The side effect were slight and temporal.
出处
《山东医药》
CAS
北大核心
2007年第3期14-15,共2页
Shandong Medical Journal
