摘要
中药是在中医药理论指导下使用的药物,其来源以植物药为主,其次是动物药、矿物药,还有小部分是化学药和生物制品。由于中药生物来源、生态环境、化学物质结构、炮制方法、代谢途径和代谢产物的多样性以及生物活性和临床应用的多样性,构成了一个庞大的复杂系统,蕴涵着许多科学问题。解析这个复杂系统的基础科学问题之一是毒性成分和毒性效应物质的阐明。伴随中药代谢的研究进展和新兴学科代谢组学的出现,形成了“基于体内过程的中药毒性成分和毒性效应物质的发现策略”,其将为中药复杂体系的研究提供新的方法和途径。
Chinese material medica is the natural therapeutic agent used under the guidance of the theories of traditional Chinese medicine. Its sources are mainly derived from plants, some derived from animals and minerals, and a few derived from chemical drugs and biologic products. It was made up into a colossal complex system because of its diversity of biological sources, ecological environments, chemical constituent structures, processing methods, processes of metabolian-disposition and their products in intra-body, biological activity and clinical use, and involved a lot of scientific problems. The elucidation of the toxic-invited constituents and toxic-effective substances is one of basic and scientific problem to clarify complex system of Chinese material medica. Along with the research progress of processes of metabolism and disposition of Chinese material medica in intra-body and metabonomics, a new and rapid-developing technology, the discovery strategy for toxic-invited constituents and toxic-effective substances on Chinese material medica based on the processes of metabolism and disposition would be made up, which will provide a new methodology and pathway to clarify of complex system of Chinese material medica.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2007年第2期67-72,共6页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家高技术领域研究计划"863"资助项目(No.2002AA2Z343C)
北京市科技专项资助项目(No.Z0004105040311)
关键词
中药体内过程
毒性成分
毒性效应物质
发现策略
processes of metabolism and disposition on Chinese material medica in intra-body
toxic-invited constituents
toxic-effective substances
discovery strategy
