摘要
目的:初步探讨化疗和未化疗的消化道肿瘤患者血清IL-10、CEA、CA724的水平及意义。方法:分别采用电化学发光和化学发光免疫测定55例消化道肿瘤化疗和未化疗、消化道良性疾病患者的血清IL-10、CEA、CA724含量,并与30例正常人比较。结果:未化疗组患者血清IL-10水平显著高于正常人组、化疗组及良性疾病组(P<0.05),但血清IL-10与CEA、CA724无相关性(P>0.05)。结论:通过对消化道肿瘤患者血清IL-10水平的检测,可以了解其肿瘤免疫抑制状态,对肿瘤的诊断和化疗预后判断有较好的临床意义。
Objective To investigate the changes of serum IL - 10 and other two tumor markers （ CEA, CA724） in patients with gastro - intestinal malignancies after previous chemotherapy. Methods Serum IL - 10 （ with CLIA） and CEA, CA724 （ with ECLIA） levels were determined in ① 14 patients with gastro - intestinal malignancies before any chemotherapy ② 30 patients with previous chemotherapy ③ 11 patients with benign gastro - intestinal disorders and ④ 30 controls. Results Serum IL - 10 levels were significandy higher in the patients without chemotherapy than those in the other groups （P 〈 0.05）. There were no correlations between the levels of IL - 10 and CEA, CA724. Conclusion The immuno - suppression cytokin IL - 10 levels might be decreased with effective chemotherapy.
出处
《放射免疫学杂志》
CAS
2007年第1期77-78,共2页
Journal of Radioimmanology
关键词
消化道肿瘤
化疗
白细胞介素-10
digestive malignancies, chemotherapy, interleukin 10（IL- 10）
