摘要
目的:探讨多肿瘤标志物蛋白芯片与化学发光检测对肿瘤诊断的临床应用价值。方法:应用多肿瘤标志物蛋白芯片与化学发光技术,对180名健康体检者和已患肿瘤的210例病人进行12种肿瘤标志物联合检测,并对检测结果进行对比分析。结果:多肿瘤标志物蛋白芯片与化学发光检测两种方法在对健康体检组阳性率和特异性经统计学分析没有显著性差异(P>0.05);对已患肿瘤的210例12种肿瘤标志物检测两种方法的检测结果为AFP、PSA、f-PSA、CA199、CA153、NSE有显著性差异(P<0.05),CA242、β-HCG、HGH、CA125、Fer、CEA没有显著性差异(P>0.05)。结论:多肿瘤标志物蛋白芯片与化学发光检测在对提高肿瘤诊断的阳性率和特异性方面具有一定的相关性,但多肿瘤标志物蛋白芯片在健康体检中的应用价值优于化学发光检测,而对确诊的肿瘤患者,化学发光检测优于多肿瘤标志物蛋白芯片检测。
Objective To investigate the clinical applicability of multi - tumor markers protein chip and CLIA for diagnosis of malignancy. Methods Combined determinations of 12 serum tumor marker were performed with multi - tumor markers protein chip and CLIA respectively in 180 controls （for routine physical examination） and 210 patients with known various types of malignancies. Results For the controls, results with chips and CLIA were about the same （ P 〉 0. 05）. In the patients, for AFP, PSA, f - PSA, CA19-9, CA15 -3 and NSE, the sensitivity and specificity were, as a whole, significantly higher with CLIA than those with chips （P 〈 0. 05）. However, there were no significant differences for CA242, β -HCG, HGH, CA125, FER and CEA with the two methods （P 〉 0. 05）. Conclusion For screening, protein chip technic was quite practical, being less expensive and more readily performed than the CLIA technic. However, the results with CLIA in the patients with known malignancies were superior to those with protein chips.
出处
《放射免疫学杂志》
CAS
2007年第1期84-87,共4页
Journal of Radioimmanology
