摘要
目的比较哈萨克(哈族)与汉族胰岛素抵抗、瘦素与血压的关系。方法抽哈、汉民族共242例研究对象,哈、汉民族各分为原发性高血压组(61例)及对照组(60例),比较两民族的胰岛素抵抗指数、瘦素,采用直线相关分析的方法分析各因素与血压的关系。结果在原发性高血压组,哈族胰岛素抵抗指数(5.8±2.2)显著高于汉族(4.9±2.0)(P<0.05);在对照组,哈族胰岛素抵抗指数(4.8±1.5)显著高于汉族(3.7±1.5)(P<0.05);哈、汉民族间瘦素水平比较差异无统计学意义(P>0.05);哈、汉民族胰岛素抵抗、瘦素均与血压呈显著正相关(P<0.05)。结论哈族胰岛素抵抗显著高于汉族,存在种族差异;哈、汉民族胰岛素抵抗、瘦素均与血压呈正相关,未见种族差异。
Objective To compare the relationship of insulin resistance, leptin and blood pressure between Kazaks and Hans nationalities. Methods Totally 242 subjects were selected from Kazaks and Hans . Both Kazak and Han subjects were individually divided into the essential hypertensive group（ n = 61）and the control group（ n = 60）. Homeostasis model assessment insulin resistance （HOMA-IR） and leptin were compared between Kazak and Han corresponding groups. Linear correlation analysis was adopted to analyze the correlation between these factors and blood pressure in Kazaks and Hans . Results For the essential hypertensive groups, HOMA-IR of Kazak subjects was significantly higher than that of Han subjects （5.8±2, 2,4.9±2.0, P 〈 0.05）;For the control groups, HOMA-IR of Kazak subjects was significantly higher than that of Han subjects （4.8±1.5,3.7± 1.5, P〈0. 05）;There was no significant difference on leptin between Kazak and Han subjects （ P〉 0.05）. Insulin resistance and leptin were in significantly positive relationship with blood pressure（ P〉0.05）. Conclusion Insulin resistance of Kazak subjects was significantly higher than that of Han subjects and national difference existed; insulin resistance and leptin were in positive correlation with blood pressure in Kazaks and Hans and no national difference existed.
出处
《临床荟萃》
CAS
北大核心
2007年第3期165-167,共3页
Clinical Focus
基金
新疆地方与民族高发病省部共建教育部重点实验室开放课题(2004-14)
关键词
高血压
胰岛素抗体
瘦素
hypertension
insulin antibodies
leptin
