摘要
目的：观察甲状腺局部注射利美达松治疗突眼性甲状腺肿（ＧＤ）的疗效。方法：ＧＤ病人４２例（男性４例，女性３８例，年龄３６±ｓ１１ａ）为治疗组，另４５例为对照组（男性５例，女性４０例，年龄３４±１０ａ），前者在抗甲状腺药物治疗基础上，行利美达松甲状腺局部注射，２．５～５ｍｇ／次，１次／２ｗｋ，４次为一个疗程，治疗１～２个疗程。对照组仅行抗甲状腺药物治疗。结果：治疗组与对照组比较：前者甲状腺体积明显缩小，且质地变软；Ｔ３，Ｔ４，及ＴＳＨ复原时间缩短；病理显示甲状腺内淋巴细胞浸润明显减少，均Ｐ＜０．０１。无明显激素样副作用。
AIM:To observe the therapeutic effects of limethason(LTS) in treating Graves'disease(GD) by the local injection of LTS into thyroid.METHODS: Forty-two patients(M4,F38,age 36± s 11 a) randomly from 87 patients with GD were injected with LTS 2.5-5 mginto thyroid , on the bases of antithyroid therapy, LTS injection was performed once per 2 wk and 4 times of injection were regarded as a therapeutic course. Patients received one or two therapeutic courses of LTS treatment.The other 45 patients(M5,F40,age 34 ± 10 a) served as control,received antithyroid therapy only. RESULTS :The thyroid volumes in LTS treatment group were obviously reduced and the thyoid textures on palpation became soften, as compared to control group.The time of recuperation of thyroid function showed by serum T3, T4 and TSH measurements was shorten(P< 0.01).The thyroid lymphocyte infiltrations after LTS injections were significantly decreased.No steroid adverse reaction was observed.CONCLUSION:LTS treatment proves to be effective and helpful for GD.
出处
《新药与临床》
CSCD
北大核心
1996年第6期337-339,共3页
关键词
利美达松
治疗
突眼性
甲状腺肿
limethason, dexamethasone, exophthalmic goiter, intralesional injections
