摘要
有机磷和氨基甲酸酯类杀虫剂的大量使用导致昆虫对其产生抗药性。酯酶是昆虫体内重要的解毒代谢酶,酯酶基因表达量上升和点突变使其代谢或结合杀虫剂的能力增强是昆虫对常用农药产生抗药性的2个重要原因。文章概述昆虫酯酶基因扩增及突变所导致的抗药性,进一步分析了酯酶突变对蛋白结构和功能的影响。
Extensive use of organophosphate and carbamate insecticides led to development of resistance in many insects. Esterase is an important metabolism enzyme. Increasing expression and point mutation of esterase gene are the two most important reasons, which make its metabolism and binding activity increase. Here esterase gene mutation and amplification conferring resistance in the insects are summarized. Furthermore the effects of esterase mutation on protein structure and function are discussed.
出处
《昆虫知识》
CSCD
北大核心
2007年第1期29-31,共3页
Entomological Knowledge
基金
粮食丰产科技工程资助项目(2004BA520A15)。
关键词
酯酶
基因扩增
点突变
esterase, gene amplification, point mutation
