摘要
目的:探讨脑挫裂伤患者血清中基质金属蛋白酶(matrix metalloproteinases,MMP)的水平与受伤严重程度的关系。方法:2002～2004年我院收治86例脑挫裂伤患者按严重程度分为4级,于伤后48h抽取静脉血并用酶联免疫吸附双抗体夹心法(ELISA法)检测血清中MMP-2和MMP-9的浓度,分别比较二者各组浓度的差异。结果:MMP-2和MMP-9在不同严重程度组间的水平差异有显著性。结论:MMP-2和MMP-9与脑挫裂伤的发展有密切关系。脑挫裂伤患者血清中MMP-2和MMP-9的水平比正常人明显增高,并且两者的水平与受伤严重程度呈正相关。血清中MMP的水平有可能作为衡量脑挫裂伤严重程度的指标。
Objective：To explore the relationship between the level of serum b^P and the degree of brain trauma. Methods：Patients admitted to the hospital from 2002 to 2004 and diagnosed as brain contusion and lacerationby CT scan were dirided into 4 groups according to traumatic degree. After 48 h of trauma, the levels of MMP-2 and MMP-9 in serum with ELISA were examined and the difference among groups was assayed. Results：The levels of MMP-2 and MMP-9 were associated closely with the degree of brain trauma. Conclusions：MMP-2 and MMP-9 are associated with the development of brain contusion and laceration. The levels of MMP-2 and MMP-9 can be indicators to exam the degree of brain contusion and laceration.
出处
《温州医学院学报》
CAS
2007年第1期41-43,共3页
Journal of Wenzhou Medical College
关键词
基质金属蛋白酶
脑挫裂伤
Matrix metalloproteinases
brain contusion and laceration
