摘要
目的建立我国慢性胰腺炎（CP）流行病学、病因、临床表现、诊断以及治疗数据库，并研究我国CP流行病学特征、病因和危险因素，以及临床表现、诊断和治疗现状，指导我国CP诊治。方法 采用多中心联合调查方法，在全国设置22个研究中心，各研究中心的专家组成专家组，专家组讨论通过并制定CP调查问卷，由计算机专业人员根据问卷编制CP流行病学调查数据库软件，各中心负责将本中心调查的病例资料录入调查软件，调查时间为1994年5月至2004年5月。结果 共收集CP1994例，我国CP发病人数从1995年的48例逐年上升到2003年的346例，发病年龄在5～85岁之间，平均年龄（48．9±15．0）岁，高峰在60岁，男女性别比例为1．86：1。我国经济发达地区发病人数较多。多元统计分析显示，长期过量饮酒、胆道疾病、胰腺外伤为主要病因，分别占35．4％、33．9％和10．5％。CP以腹痛为主要临床症状，占76．8％。诊断方法以EUS和ERCP诊断敏感性和特异性较高。治疗方法以药物和内镜治疗为主，分别占69．1％、16．8％。CP的预后以及CP同胰腺癌的关系有待进一步随访研究。结论 我国CP发病人数呈逐年上升趋势；酒精已经成为我国CP的主要致病因素；EUS和ERCP为诊断CP的主要方法；药物及内镜治疗是主要治疗措施。
Objective A multi-center survey was conducted of chronic pancreatitis （CP） in different areas of China. The main objective of the survey was to generate a database containing information regarding the etiology, clinical presentation, diagnostic work-up, and management of CP in China. Methods A structured questionnaire was designed by the expert participants, and a software was written based on the questionnaire. Data were collected from 22 hospitals using the software. The time limit was from May 1994 to May 2004. Results The prevalence of CP was found to be on the increase year by year. Alcohol was the most common etiological factor （35.4% ）, while biliary diseases ranked as the second etiological factor （33.9%）. Pain was the most common clinical feature. Diabetes and steatorrhea were uncommon. With regard to the diagnosis of CP, EUS and ERCP were the ＂gold criterion＂. Especially EUS has high sensitivity and specificity. Pancreatic enzymes were the chief and initial medical treatment for relieving pain in CP. Endotherapy was suggested as the therapy of choice if medical therapy failed. Surgery was offered only after the failure of endotherapy. Conclusions The survey summarizes the prevalent types and presentation of CP, common management practices, and also knowledge deficits about CP in China. These findings might help focus attention on the research oriorities for CP in this field.
出处
《胰腺病学》
2007年第1期1-5,共5页
Chinese JOurnal of Pancreatology
关键词
胰腺炎
慢性
流行病学
数据收集
多中心研究
Pancreatitis, chronic
Epidemiology
Data collection
Multicenter studies
