摘要
目的探讨冠心病不同临床表现时血管内皮细胞的激活情况。方法通过酶联免疫吸附法检测28例急性心机梗死、29例不稳定型心绞痛、25例稳定型心绞痛患者以及19例冠脉造影结果正常的对照个体的血清可溶性E选择素水平。结果急性心机梗死和不稳定型心绞痛患者的血清可溶性E选择素水平比较差异无统计学意义,分别为(62.2±6.7)ng/m l和(58.9±7.2)ng/m l,但这两组患者血清可溶性E选择素水平却较稳定型心绞痛患者(34.6±4.5)ng/m l和对照组(31.7±4.7)ng/m l明显增高,后两组个体的血清可溶性E选择素水平也相近。结论血清可溶性E选择素水平的升高反映缺血心肌发生了急性炎症反应,其是确定急性冠脉综合征患者冠状动脉粥样斑块存在不稳定性的有效指标。
Objective To investigate the activation of the endothelial cell in different clinical presentations of coronary heart disease. Methods Serum levels of soluble E - selectin of 28 patients with acute myocardial infarction,29 patients with unstable angina pectoris,25 patients with stable angina pectoris and 19 control subjects with angiographically documented normal coronary arteries were measured by enzyme - like immunoserbent assay. Results Serum levels of soluble E - selectin were not different in acute myocardial infarction （62.2 ± 6. 7） ng/ml and unstable angina pectoris （58. 9 ± 7.2） ng/ml groups. But it was higher in acute coronary syndrone group compared with stable angina pectoris group （34. 6 ± 4. 5 ）ng/ml and control subjects （31.7 ± 4. 7） ng/ml. Serum levels of soluble E - selectin were similar in stable angina pectoris group and control subjects. Conclusion Increased serum levels of soluble E - selectin reflected acute inflammory response to myocardial ischemia and is useful to define the unstabitity of plaque of coronary arteries in acute coronary syndrome patients.
出处
《临床医学》
CAS
2007年第1期88-89,共2页
Clinical Medicine
关键词
可溶性E选择素
急性心机梗死
不稳定型心绞痛
稳定型心绞痛
Soluble E - selectin
Acute myocardial infarction
Unstable angina pectoris
Stable angina pectofis
