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福辛普利钠对实验性糖尿病肾病大鼠早期肾脏血管内皮生长因子的影响 被引量：1

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摘要 目的:观察福辛普利钠对实验性糖尿病肾病大鼠早期肾脏病变的作用,并探讨其作用机制。方法:将雄性Wistar大鼠随机分为正常对照组、糖尿病肾病组和福辛普利钠治疗组,每组各12只,分别于灌胃治疗2、4周留取肾组织,采用免疫组织化学方法检测肾小球血管内皮生长因子(VEGF)的表达并进行半定量分析。结果:糖尿病肾病大鼠肾组织中VEGF表达的分布范围及强度与正常对照组比较,第2、4周均显著升高(P<0.01)。福辛普利钠治疗4周后,VEGF表达的分布范围及强度与糖尿病肾病组相比均明显下降。结论:肾局部VEGF表达增加参与了糖尿病肾病的发生,福辛普利钠可抑制糖尿病肾病大鼠肾VEGF的表达,这可能是其发挥肾保护作用的机制之一。
作者 曹宁 郑红光 关欣 王沙西
机构地区 沈阳军区总医院肾内科
出处 《实用医学杂志》 CAS 2007年第2期164-166,共3页 The Journal of Practical Medicine
关键词 糖尿病肾病 大鼠 血管内皮生长因子 福辛普利
分类号 R587.2 [医药卫生—内分泌]
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参考文献6

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同被引文献31

  • 1叶春玲,庄岚,卢超霞,周光雄,钟玲.2型糖尿病大鼠模型的肾脏和动脉血管并发症[J].中国实验动物学报,2007,15(3):161-165. 被引量：8
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实用医学杂志
2007年 第2期

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