摘要
目的:核转录因子κB是一种可激活的转录因子,存在于脑内神经元、神经胶质和神经干细胞中,参与体内炎症和免疫反应、发育、凋亡和抗凋亡等众多生物过程。本文就核转录因子κB在神经干细胞增殖、迁移和分化中的作用进行综述。资料来源:应用计算机检索PUBMED1987-01/2006-09期间的相关文章,检索词为“Neural stem cell,Proliferation,Migration,Differentiation/stem cell,Differentiation/NF-κB”,并限定文章语言种类为English。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与核转录因子κB在神经干细胞增殖、迁移和分化中的作用相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到61篇相关文献,32篇文献符合纳入标准,排除的29篇文献为内容陈旧或重复。符合纳入标准的32篇文献中,4篇涉及成体神经干细胞,3篇涉及转录因子κB/Rel家族和I-κB蛋白,11篇涉及核转录因子κB与神经干细胞增殖,8篇涉及核转录因子κB与神经干细胞的迁移,6篇涉及核转录因子κB与神经干细胞分化。资料综合:神经干细胞是一类具有自我更新、高度增殖、定向迁移和多向分化潜能的细胞群体,可存在于成熟脑的特定区域。神经干细胞的发育经历着分裂、迁移和分化成熟的过程。核转录因子κB是一种具有多向转录调节作用的蛋白质,可与特定DNA片段结合,调节相关基因的转录。核转录因子κB参与了促红细胞生成素、缺氧及脑损伤等引起的神经干细胞增殖,在使用其抑制剂如β-淀粉样蛋白、一氧化氮等后,神经干细胞增殖减少。在神经干细胞迁移方面,核转录因子κB通过诱导巨噬细胞化学诱导蛋白1、干细胞因子、基质细胞衍生因子等的表达而达到促进神经干细胞迁移的作用。神经干细胞向星型胶质细胞、神经元、少突胶质细胞和神经胶质谱系分化是由特定的信号级联决定的,细胞因子白细胞介素6家族通过激活核转录因子κB而促进神经干细胞向星形胶质细胞的分化,成神经瘤细胞的分化过程必需有核转录因子κB的参与。结论:大量证据表明在神经干细胞复杂的转录调节机制中,核转录因子κB发挥着重要的作用。
OBJECTIVE： Nuclear factor （NF）-κB is an inducible transcription factor detected in neurons, glial and neural stem calls. It is involved in many biological processes such as inflammation and innate immunity, development, apoptosis and anti-apoptosis. This text is aimed to explain the roles of NF-κB in proliferation, migration and differentiation of neural stem calls. DATA SOURCES： The related literatures between January 1987 and September 2006 ware collected from the PUBMED with the key words of ＂Neural stem call, Proliferation, Migration, Differentiation/stem call, Differentiation/NF-κB＂ in English. STUDY SELECTION： Firstly the articles were checked and quotations attached to these articles were looked over. Inclusive criteria： the content of the articles must be correlated with roles of NF-κB in proliferation, migration, differentiation of neural stem call. Exclusive criteria： Repetitive research or articles of Meta analysis. DATA EXTRACTION： There ware 61 correlated articles, 32 articles accorded with inclusive criteria, and 29 articles excluded ware olden or repetitive in content. In 32 collected articles, 4 articles referred to adult neural stem call, 3 artides referred to NF-κB/Rel family and I -κB, 11 artides referred to NF-κB and proliferation of neural stem call, 8 articles referred to NF-κB and migration of neural stem call and 6 articles referred to NF-κB and differentiation of neural stem call. DATA SYNTHESIS： Neural stem calls ware characterized by the capability to undergo self-renewal, call divisions, to migrate and to differentiate into multiple call types. Stem calls within the adult brain ware found within special areas. Neural stem calls experienced the processes of dissociation, immigration and differentiation. NF-κB was a transcription factor, which can bind to specific DNA-sequencas and regulate transcription. NF-κB was involved in induction of proliferation under erythropoietin （EPO）, hypoxia conditions and brain injury. The inhibitors of NF-κB such as beta-peptide, nitric oxide acted in negative manner on proliferation of neural stem cells. In migration of neural stem call, NF-κB was necessary for induction of migration caused by macrophage chemo attractant protein-I, stem call factor, stromal call derived factor. The differentiation of neural stem calls toward astrocytic, neuronal, oligodendrccytic and glial lineages was determined by specific signaling cascades. Interleukin-6 family could accelerate the differentiation of neural stem calls to horizontal calls. The differentiation of neuroblastoma calls could be joined by NF-κB. CONCLUSION： A great quantity of evidences verifies that NF-κB plays a crucial role in the complicated regulatory mechanism of transcription of neural stem cells.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第7期1341-1344,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
