摘要
目的了解支气管哮喘(简称哮喘)患者外周血胰岛素与外周血淋巴细胞胰岛素受体的情况。方法哮喘患者40例,其中初诊轻中度非激素治疗组(简称未治疗组)20例,轻中度慢性持续期激素治疗组20例(简称治疗组);健康对照20例。清晨空腹采血,测定外周血白细胞总数和分类计数;测定空腹血糖、胰岛素、胰岛素受体;进行肺功能测定。结果未治疗组和治疗组哮喘患者外周血中嗜酸粒细胞计数显著高于对照组[(4.04±2.57)%和(4.24±2.34)%比(0.90±1.38)%,P<0.05]。未治疗组哮喘患者胰岛素、胰岛素受体水平显著高于对照组[胰岛素(13.00±5.20)mIU/L比(10.08±3.79)mIU/L;胰岛素受体(2.59±3.11)%比(0.99±0.62)%;P均<0.05]。结论哮喘患者在炎症状态下胰岛素分泌增多,胰岛素受体表达增加。
Objective To investigate the changes of insulin and insulin receptor in asthma patients. Methods Forty asthma patients were allocated into two groups： 20 newly diagnosed treatment-naive mild- moderate asthma patients, 20 mild-moderate persistent asthma patients treated with inhaled corticosteroid. 20 healthy volunteers were enrolled as normal control. Blood samples were obtained from 40 asthma patients and 20 healthy volunteers. Total and differential leukocyte counts, blood glucose concentration and serum insulin concentration were measured. The level of lymphocyte insulin receptor in peripheral blood were assayed by flow cytomertry. Pulmonary function were performed at the same time. Results The numbers of eosinophil in the two asthma groups were significantly higher than those in the normal control group [ （4.04 ± 2.57） % and （4.24 ± 2.34）% vs （0.90± 1.38）% ,P 〈0.05） ,the levels of iasulin and insulin receptor in the treatment-naive group were significantly higher than those in the control group [ insulin： （ 13.00 ± 5.20） mIU/L vs （ 10.08 ± 3.79）mIU/L,P 〈 0.05; insulin receptor： （2.59 ± 3.11）% vs （0.99 ± 0.62）%, P 〈 0.05）. Conclusion Insulin secretion and insulin receptor expression in asthma patients are increased in the presence of inflammation.
出处
《中国呼吸与危重监护杂志》
CAS
2007年第1期8-11,共4页
Chinese Journal of Respiratory and Critical Care Medicine
基金
国家自然科学基金(编号:30370610)
