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Napsin A mRNA在原发性肺腺癌中表达的临床意义 被引量：4

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摘要 本研究以Napsin A（novel aspartic proteinase A）为指标，对47例原发性肺腺癌手术切除标本Napsin A mRNA进行实时荧光定量PCR研究，并与癌旁正常肺组织比较。
作者 郭峰 卢兆桐 耿明 邹志强 丁吉元 李明
机构地区 济南军区总医院胸外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2007年第2期250-250,共1页 Chinese Journal of Experimental Surgery
关键词 原发性肺腺癌 MRNA 临床意义 实时荧光定量PCR 癌旁正常肺组织 手术切除标本
分类号 R686 [医药卫生—骨科学]
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参考文献3

  • 1Mori K,Kon Y,Konno A,et al.Cellular distribution of napsin (kidney-derived aspartic protease-like protein,KAP) mRNA in the kidney,lung and lymphatic organs of adult and developing mice.Arch Histol Cytol,2001,64:319-327.
  • 2Ueno T,Linder S,Na CL,et al.Processing of pulmonary surfactant protein B by napsin and cathepsin H.J Biol Chem,2004,279:16178-16184.
  • 3Ueno T,Linder S,Elmberger G.Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.Br J Cancer,2003,88:1229-1233.

同被引文献49

  • 1Kim KK,Kugler MC,Wolters PJ,et al.Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.Proc Nat Acad Sci USA,2006,103:13180-13185.
  • 2Sime PJ,O'Reilly KMA.Fibrosis of the lung and other tissues:new concepts in pathogenesis and treatment.Clin Immunol,2001,99:308-319.
  • 3Tatnell PJ,Powell DJ,Hill J,et al.Napsins:new human aspartic proteinases.Distinction between two closely related genes.FEBS Lett,1998,441:43-48.
  • 4Ueno T,Linder S,Elmberger G,et al.Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.Br J Carcer,2003,88:1229-1233.
  • 5Ramsay A,Marshall JF,Hart IR,et al.Integrin trafficking and its role in cancer metastasis.J Cancer Metastasis Rev,2007,26:567-578.
  • 6Hsia DA,Mitra SK,Hauck CR,et al.Differential regulation of cell motility and invasion by FAK.J Cell Biol,2003,160:753-767.
  • 7Matter ML,Ruoslahti E.A signaling pathway from the alpha5betal and alpha (v)beta3 integrins that elevates bcl-2 transcription.J Biol Chem,2001,276:27757-27763.
  • 8Yee KL,Weaver VM,Hammer DA,et al.Integrin-mediated signaling through the MAP-kinase pathway.J IET Syst Biol,2008,2:8-15.
  • 9Xie B,Zhao J,Itagawa M,et al.Focal adhesion kinase activates Statl in integrin-mediated cell migration and adhesion.J Biol Chem,2001,276:19512-19523.
  • 10Aguirre Ghiso JA.Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo.Oncogene,2002,21:2513-2524.

引证文献4

二级引证文献14

中华实验外科杂志
2007年 第2期

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