摘要
目的:探讨聚维酮(PVP)在体外加阿霉素(ADM)后诱导EJ细胞发生凋亡的情况以及一些相关机制。方法:应用流式细胞仪(FCM)检测ADM诱导EJ细胞的凋亡率、PVP+EJ细胞的凋亡率以及PVP+ADM对EJ细胞的诱导凋亡率的情况。结果:PVP对ADM诱导膀胱癌EJ细胞凋亡无影响。结论:PVP在整个诱导过程中并没有协同作用,只起到粘附作用,使得药物停留在EJ细胞表面的作用时间延长,从而达到大量杀伤EJ细胞的作用。
Objective： To study the effect of PVP on EJ cell apoptosis resulted from ADM in vitro and the related mechanism. Methods：The apeptosis of EJ cells treated with ADM,those treated with PVP and those treated with ADM and PVP were detected by flow cytometry （FCM） respectively. Results： PVP had no influences on the apeptosis of EJ cells resulted from ADM. Conclusion：The effect of PVP on EJ cells apeptosis is not cooperated but conglutination. PVP could extend the time of ADM of resting on the surface of EJcells and kill a great deal of EJ cells.
出处
《中国卫生检验杂志》
CAS
2007年第1期104-105,共2页
Chinese Journal of Health Laboratory Technology
